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C06C3.3 Doublecortin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182302, updated on 4-Jan-2025

Summary

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Official Symbol
C06C3.3
Official Full Name
Doublecortin domain-containing protein
Primary source
WormBase:WBGene00007374
Locus tag
CELE_C06C3.3
See related
AllianceGenome:WB:WBGene00007374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in intracellular signal transduction. Predicted to be active in microtubule and microtubule organizing center. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; dyslexia; nephronophthisis 19; and sclerosing cholangitis. Orthologous to human DCDC2 (doublecortin domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See C06C3.3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (9369074..9372493, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Coelomocyte uptake defective protein 15 Neighboring gene ncRNA Neighboring gene cGMP-dependent protein kinase interacting domain-containing protein Neighboring gene Secreted protein Neighboring gene FBD domain-containing protein Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Doublecortin domain-containing protein
NP_495995.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9369074..9372493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063594.4 → NP_495995.2  Doublecortin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495995.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17711
    Conserved Domains (2) summary
    PTZ00121
    Location:194 → 556
    PTZ00121; MAEBL; Provisional
    smart00537
    Location:13 → 98
    DCX; Domain in the Doublecortin (DCX) gene product
Nucleotide Protein
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