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nonu-1 Smr domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 184951, updated on 4-Jan-2025

Summary

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Official Symbol
nonu-1
Official Full Name
Smr domain-containing protein
Primary source
WormBase:WBGene00017811
Locus tag
CELE_F26A1.13
See related
AllianceGenome:WB:WBGene00017811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable endonuclease activity. Is expressed in body wall musculature; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to several human genes including CNP (2',3'-cyclic nucleotide 3' phosphodiesterase); N4BP2 (NEDD4 binding protein 2); and N4BP2L1 (NEDD4 binding protein 2 like 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nonu-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (4846582..4849907, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ACB domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Putative forkhead-related transcription factor fkh-5 Neighboring gene Non-structural maintenance of chromosomes element 4 Neighboring gene Cell death protein 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitination of stalled ribosomes enables mRNA decay via HBS-1 and NONU-1 in vivo. Monem PC, et al. PLoS Genet, 2023 Jan. PMID 36626369, Free PMC Article
  2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Smr domain-containing protein
NP_001379779.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4846582..4849907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393328.1 → NP_001379779.1  Smr domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19803
    Conserved Domains (2) summary
    smart00463
    Location:575 → 656
    SMR; Small MutS-related domain
    pfam13671
    Location:30 → 134
    AAA_33; AAA domain
Nucleotide Protein
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