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ddl-2 WASH complex subunit homolog 1 [ Caenorhabditis elegans ]

Gene ID: 190025, updated on 9-Dec-2024

Summary

Official Symbol
ddl-2
Official Full Name
WASH complex subunit homolog 1
Primary source
WormBase:WBGene00013000
Locus tag
CELE_Y48E1B.1
See related
AllianceGenome:WB:WBGene00013000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable alpha-tubulin binding activity and gamma-tubulin binding activity. Involved in cytoplasmic sequestering of protein and determination of adult lifespan. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome and recycling endosome. Is expressed in neurons. Orthologous to several human genes including WASHC1 (WASH complex subunit 1) and WASH2P (WASP family homolog 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See ddl-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (13541506..13547645, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class epsilon-45 Neighboring gene Sorting nexin-12 Neighboring gene G domain-containing protein Neighboring gene PIG-P domain-containing protein Neighboring gene Geranylgeranyl transferase type I subunit beta;Geranylgeranyl transferase type-1 subunit beta Neighboring gene Large ribosomal subunit protein mL37

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding  
enables alpha-tubulin binding  
enables alpha-tubulin binding  
enables gamma-tubulin binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation  
involved_in Arp2/3 complex-mediated actin nucleation  
involved_in cytoplasmic sequestering of protein PubMed 
involved_in determination of adult lifespan PubMed 
involved_in endocytic recycling  
involved_in exocytosis  
involved_in retrograde transport, endosome to Golgi  
Component Evidence Code Pubs
part_of WASH complex  
part_of WASH complex  
located_in cytosol  
is_active_in early endosome  
located_in early endosome  
is_active_in recycling endosome  

General protein information

Preferred Names
WASH complex subunit homolog 1
NP_496847.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13541506..13547645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064446.5 → NP_496847.1  WASH complex subunit homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496847.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18195
    Conserved Domains (1) summary
    pfam11945
    Location:2 → 283
    WASH_WAHD; WAHD domain of WASH complex
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