U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WDR7 WD repeat domain 7 [ Homo sapiens (human) ]

Gene ID: 23335, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
WDR7provided by HGNC
Official Full Name
WD repeat domain 7provided by HGNC
Primary source
HGNC:HGNC:13490
See related
Ensembl:ENSG00000091157 MIM:613473; AllianceGenome:HGNC:13490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAG
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 12.4), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See WDR7 in Genome Data Viewer
Location:
18q21.31
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (56651359..57036606)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (56853334..57234168)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (54318590..54697023)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372135 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:54304875-54305860 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:54305861-54306845 Neighboring gene Sharpr-MPRA regulatory region 10710 Neighboring gene thioredoxin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13364 Neighboring gene NANOG hESC enhancer GRCh37_chr18:54503488-54503989 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54540953-54541541 Neighboring gene uncharacterized LOC124904382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54653903-54654752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:54679651-54680151 Neighboring gene uncharacterized LOC105372136 Neighboring gene WDR7 overlapping transcript 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolution of a Human-Specific Tandem Repeat Associated with ALS. Course MM, et al. Am J Hum Genet, 2020 Sep 3. PMID 32750315, Free PMC Article
  2. Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization. Sanders S, et al. Cytogenet Cell Genet, 2000. PMID 10828621
  3. A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter. Kawabe H, et al. Genes Cells, 2003 Jun. PMID 12786944
  4. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Edwards AC, et al. Psychiatr Genet, 2012 Feb. PMID 22064162, Free PMC Article
  5. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Yu D, et al. Am J Psychiatry, 2015 Jan. PMID 25158072, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evolution of a Human-Specific Tandem Repeat Associated with ALS.
    Title: Evolution of a Human-Specific Tandem Repeat Associated with ALS.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
EBI GWAS Catalog
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study of comorbid depressive syndrome and alcohol dependence.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0541

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WD repeat-containing protein 7
Names
TGF-beta resistance associated
TGF-beta resistance-associated protein TRAG
rabconnectin-3 beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382485.1 → NP_001369414.1  WD repeat-containing protein 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007052, AC008006, AC012301
    Consensus CDS
    CCDS11963.1
    Conserved Domains (2) summary
    sd00039
    Location:22 → 62
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:408 → 598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001382487.1 → NP_001369416.1  WD repeat-containing protein 7 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007052, AC008006, AC012301
    Consensus CDS
    CCDS11962.1
    UniProtKB/Swiss-Prot
    A7E2C8, Q86UX5, Q86VP2, Q96PS7, Q9Y4E6
    Conserved Domains (2) summary
    sd00039
    Location:22 → 62
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:408 → 598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_015285.3 → NP_056100.2  WD repeat-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_056100.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007052, AC008006, AC012301
    Consensus CDS
    CCDS11962.1
    UniProtKB/Swiss-Prot
    A7E2C8, Q86UX5, Q86VP2, Q96PS7, Q9Y4E6
    Related
    ENSP00000254442.3, ENST00000254442.8
    Conserved Domains (2) summary
    sd00039
    Location:22 → 62
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:408 → 598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_052834.3 → NP_443066.2  WD repeat-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_443066.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon within the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC007052, AC008006, AC012301
    Consensus CDS
    CCDS11963.1
    UniProtKB/Swiss-Prot
    Q9Y4E6
    Related
    ENSP00000350187.2, ENST00000357574.7
    Conserved Domains (2) summary
    sd00039
    Location:22 → 62
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:408 → 598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    56651359..57036606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525888.3 → XP_011524190.1  WD repeat-containing protein 7 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:341 → 592
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:22 → 62
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:408 → 598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_047437422.1 → XP_047293378.1  WD repeat-containing protein 7 isoform X2

  3. XM_047437423.1 → XP_047293379.1  WD repeat-containing protein 7 isoform X3

  4. XM_047437424.1 → XP_047293380.1  WD repeat-containing protein 7 isoform X4

  5. XM_017025683.1 → XP_016881172.1  WD repeat-containing protein 7 isoform X5

    Conserved Domains (3) summary
    COG2319
    Location:851 → 919
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:849 → 883
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:849 → 918
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_007066131.1 RNA Sequence

  2. XR_007066132.1 RNA Sequence

  3. XR_007066133.1 RNA Sequence

  4. XR_007066134.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    56853334..57234168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318420.1 → XP_054174395.1  WD repeat-containing protein 7 isoform X1

  2. XM_054318421.1 → XP_054174396.1  WD repeat-containing protein 7 isoform X2

  3. XM_054318422.1 → XP_054174397.1  WD repeat-containing protein 7 isoform X3

  4. XM_054318423.1 → XP_054174398.1  WD repeat-containing protein 7 isoform X4

  5. XM_054318424.1 → XP_054174399.1  WD repeat-containing protein 7 isoform X5

RNA

  1. XR_008484989.1 RNA Sequence

  2. XR_008484990.1 RNA Sequence

  3. XR_008484991.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4E6.2 GenPept UniProtKB/Swiss-Prot:Q9Y4E6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools