FN1 fibronectin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FN1provided by HGNC
Official Full Name: fibronectin 1provided by HGNC
Primary source: HGNC:HGNC:3778
See related: Ensembl:ENSG00000115414 MIM:135600; AllianceGenome:HGNC:3778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF
Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Expression: Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q35

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (215360865..215436068, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (215845895..215921094, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (216225588..216300791, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Silico Insights Reveal Fibronectin 1 as a Theranostic Marker in Gastric Cancer.
Title: In Silico Insights Reveal Fibronectin 1 as a Theranostic Marker in Gastric Cancer.
The extracellular matrix protein fibronectin promotes metanephric kidney development.
Title: The extracellular matrix protein fibronectin promotes metanephric kidney development.
Rare genetic variation in fibronectin 1 (FN1) protects against APOEepsilon4 in Alzheimer's disease.
Title: Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.
Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
Title: Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.
Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.
Title: Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.
LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
Title: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.
Title: Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.
Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
Title: Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
Fibronectin sensitizes activation of contractility, YAP, and NF-kappaB in nucleus pulposus cells.
Title: Fibronectin sensitizes activation of contractility, YAP, and NF-κB in nucleus pulposus cells.
FN1 and cancer-associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma.
Title: FN1 and cancer-associated fibroblasts markers influence immune microenvironment in clear cell renal cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (548)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Glomerulopathy with fibronectin deposits 2 MedGen: C1866075 OMIM: 601894 GeneReviews: Not available	Compare labs
Spondylometaphyseal dysplasia - Sutcliffe type MedGen: C0432221 OMIM: 184255 GeneReviews: Spondylometaphyseal Dysplasia, Corner Fracture Type	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells	PubMed
	env	Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160	PubMed
	env	HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4	PubMed
Envelope transmembrane glycoprotein gp41	env	Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding	PubMed
Nef	nef	Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines	PubMed
Tat	tat	HIV-1 Tat competes with fibronectin for binding to integrins	PubMed
	tat	Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells	PubMed
	tat	HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells	PubMed
retropepsin	gag-pol	The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78451 (e-PCR)
- UniSTS:40194

D1S2891 (e-PCR), detects polymorphism
- UniSTS:10500

D2S2635 (e-PCR)
- UniSTS:51217

RH47963 (e-PCR)
- UniSTS:65045

GDB:344700 (e-PCR)
- UniSTS:156694

RH102231 (e-PCR)
- UniSTS:96565

FN1 (e-PCR), detects polymorphism
- UniSTS:264012

GDB:181245 (e-PCR)
- UniSTS:155213

D10S16 (e-PCR)
- UniSTS:155756

WIAF-2175 (e-PCR)
- UniSTS:4474

D1S2872 (e-PCR)
- UniSTS:54907

D1S249 (e-PCR), detects polymorphism
- UniSTS:73353

SHGC-33209 (e-PCR)
- UniSTS:83085

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-57713 (e-PCR)
- UniSTS:69785

RH98726 (e-PCR)
- UniSTS:86954

SHGC-83082 (e-PCR)
- UniSTS:101310

FN1 (e-PCR), detects polymorphism
- UniSTS:105165

PMC115222P2 (e-PCR)
- UniSTS:270295

RH102905 (e-PCR)
- UniSTS:97239

D1S2782 (e-PCR), detects polymorphism
- UniSTS:49643

SHGC-11640 (e-PCR)
- UniSTS:46574

Clone Names

DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables collagen binding	NAS Non-traceable Author Statement more info	PubMed
enables extracellular matrix structural constituent	HDA more info	PubMed
enables extracellular matrix structural constituent	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in biological process involved in interaction with symbiont	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-independent cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in endodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration involved in autonomic nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in peptide cross-linking	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	NAS Non-traceable Author Statement more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in blood microparticle	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of fibrinogen complex	IDA Inferred from Direct Assay more info	PubMed
part_of fibrinogen complex	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: fibronectin

Names: cold-insoluble globulin; epididymis secretory sperm binding protein; lnc-ABCA12-8; migration-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012196.2 RefSeqGene

Range

5000..80203

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306129.2 → NP_001293058.2 fibronectin isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS77526.1

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000323534.6, ENST00000323926.10

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2354 → 2393

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1995 → 2075

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1621

fn3; Fibronectin type III domain
NM_001306130.2 → NP_001293059.2 fibronectin isoform 9 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS77525.1

UniProtKB/TrEMBL

A0A384MR03

Related

ENSP00000399538.2, ENST00000432072.6

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2175 → 2214

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1905 → 1985

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1621

fn3; Fibronectin type III domain
NM_001306131.2 → NP_001293060.2 fibronectin isoform 10 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS77523.1

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000415018.1, ENST00000443816.5

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2173 → 2212

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1814 → 1894

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1449 → 1530

fn3; Fibronectin type III domain
NM_001306132.2 → NP_001293061.2 fibronectin isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS77522.1

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000394423.1, ENST00000421182.5

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2148 → 2187

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1814 → 1894

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1449 → 1530

fn3; Fibronectin type III domain
NM_001365517.2 → NP_001352446.1 fibronectin isoform 12 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

UniProtKB/TrEMBL

B7ZLE5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2295 → 2334

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1619

fn3; Fibronectin type III domain
NM_001365518.2 → NP_001352447.1 fibronectin isoform 13 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS92940.1

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000352696.1, ENST00000359671.5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2294 → 2333

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1449 → 1528

fn3; Fibronectin type III domain
NM_001365519.2 → NP_001352448.1 fibronectin isoform 14 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

UniProtKB/TrEMBL

B7ZLE5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2270 → 2309

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1619

fn3; Fibronectin type III domain
NM_001365520.2 → NP_001352449.1 fibronectin isoform 15 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

UniProtKB/TrEMBL

B7ZLE5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2269 → 2308

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1449 → 1528

fn3; Fibronectin type III domain
NM_001365521.2 → NP_001352450.1 fibronectin isoform 16 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

UniProtKB/TrEMBL

B7ZLE5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2264 → 2303

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1619

fn3; Fibronectin type III domain
NM_001365522.2 → NP_001352451.1 fibronectin isoform 17 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

UniProtKB/TrEMBL

B7ZLE5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2239 → 2278

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1619

fn3; Fibronectin type III domain
NM_001365523.2 → NP_001352452.1 fibronectin isoform 18 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

UniProtKB/TrEMBL

B7ZLE5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2179 → 2218

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1449 → 1528

fn3; Fibronectin type III domain
NM_001365524.2 → NP_001352453.1 fibronectin isoform 19 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

UniProtKB/TrEMBL

A0A384MR03

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2174 → 2213

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1449 → 1528

fn3; Fibronectin type III domain
NM_002026.4 → NP_002017.2 fibronectin isoform 3 preproprotein

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS2399.1

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000338200.4, ENST00000336916.8
NM_054034.3 → NP_473375.2 fibronectin isoform 7 preproprotein

See identical proteins and their annotated locations for NP_473375.2

Status: REVIEWED

Source sequence(s)

AC012462

Consensus CDS

CCDS46512.1

UniProtKB/Swiss-Prot

P02751

Related

ENSP00000398907.1, ENST00000426059.1

Conserved Domains (4) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:52 → 89

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain
NM_212474.3 → NP_997639.2 fibronectin isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS2400.1

UniProtKB/TrEMBL

A0A384MR03

Related

ENSP00000350534.4, ENST00000357867.8
NM_212476.3 → NP_997641.2 fibronectin isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS42813.1

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000348285.4, ENST00000356005.8
NM_212478.3 → NP_997643.2 fibronectin isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS46510.1

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000410422.1, ENST00000446046.5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

smart00060
Location:1268 → 1347

FN3; Fibronectin type 3 domain

cd00061
Location:2238 → 2277

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1904 → 1984

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_212482.4 → NP_997647.2 fibronectin isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC012462, AC073284

Consensus CDS

CCDS42814.1

UniProtKB/Swiss-Prot

B7ZLF0, E9PE77, E9PG29, O95609, O95610, P02751, Q14312, Q14325, Q14326, Q17RV7, Q53S27, Q564H7, Q585T2, Q59EH1, Q60FE4, Q68DP8, Q68DP9, Q68DT4, Q6LDP6, Q6MZS0, Q6MZU5, Q6N025, Q6N0A6, Q7Z391, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2

UniProtKB/TrEMBL

B7ZLE5

Related

ENSP00000346839.4, ENST00000354785.11

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:186 → 230

FN1; Fibronectin type 1 domain

cd00061
Location:2385 → 2424

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1995 → 2075

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:231 → 270

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1621

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

215360865..215436068 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

215845895..215921094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_212475.1: Suppressed sequence

Description

NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.