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clr2 SHREC complex subunit Clr2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542596, updated on 18-Sep-2024

Summary

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Official Symbol
clr2
Official Full Name
SHREC complex subunit Clr2
Primary source
PomBase:SPAC1B3.17
Locus tag
SPOM_SPAC1B3.17
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See clr2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4964493..4966980)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative mitochondrial ribosomal protein subunit S18 Neighboring gene ncRNA Neighboring gene Pig-U family GPI transamidase subunit Neighboring gene ribosome biogenesis protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe. Steinhauf D, et al. PLoS One, 2014. PMID 24475199, Free PMC Article
  2. Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Thon G, et al. Genetics, 1994 Sep. PMID 8001791, Free PMC Article
  3. SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Job G, et al. Mol Cell, 2016 Apr 21. PMID 27105116, Free PMC Article
  4. Mutations in rik1, clr2, clr3 and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Ekwall K, et al. Genetics, 1994 Jan. PMID 8138176, Free PMC Article
  5. A novel jmjC domain protein modulates heterochromatization in fission yeast. Ayoub N, et al. Mol Cell Biol, 2003 Jun. PMID 12773576, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clr2 plays a major role in mating-type and rDNA silencing, and has weaker effects on centromeric silencing.
    Title: Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in CENP-A containing chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SHREC complex EXP
Inferred from Experiment
more info
 PubMed 
part_of SHREC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SHREC complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IEA
Inferred from Electronic Annotation
more info
  
located_in mating-type region heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in subtelomeric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SHREC complex subunit Clr2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4964493..4966980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020230.3 → NP_594802.1  SHREC complex subunit Clr2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594802.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13881
    Conserved Domains (2) summary
    pfam10383
    Location:367 → 486
    Clr2; Transcription-silencing protein Clr2
    pfam16761
    Location:131 → 198
    Clr2_transil; Transcription-silencing protein, cryptic loci regulator Clr2
Nucleotide Protein
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