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Ddx24 DEAD box helicase 24 [ Mus musculus (house mouse) ]

Gene ID: 27225, updated on 27-Nov-2024

Summary

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Official Symbol
Ddx24provided by MGI
Official Full Name
DEAD box helicase 24provided by MGI
Primary source
MGI:MGI:1351337
See related
Ensembl:ENSMUSG00000041645 AllianceGenome:MGI:1351337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700055J08Rik; 2510027P10Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be active in nucleolus. Orthologous to human DDX24 (DEAD-box helicase 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 38.5), cortex adult (RPKM 31.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx24 in Genome Data Viewer
Location:
12 E; 12 52.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103374235..103392106, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103407976..103425847, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 15523 Neighboring gene STARR-positive B cell enhancer ABC_E7174 Neighboring gene OTU domain, ubiquitin aldehyde binding 2 Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene predicted gene, 53758 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability. Gan H, et al. Int Immunopharmacol, 2024 Mar 10. PMID 38354508
  2. DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling. Ma Z, et al. PLoS Pathog, 2013 Oct. PMID 24204270, Free PMC Article
  3. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. Zhao Y, et al. Genomics, 2000 Aug 1. PMID 10936056
  4. DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App(N-LF) Mice and Influences Presymptomatic Pathology. Axenhus M, et al. Int J Mol Sci, 2024 Mar 23. PMID 38612434, Free PMC Article
  5. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App[N-LF] Mice and Influences Presymptomatic Pathology.
    Title: DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App(N-LF) Mice and Influences Presymptomatic Pathology.
  2. Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability.
    Title: Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability.
  3. data provide a new function for DDX24 and help explain innate immune gene regulation, mechanisms that may additionally provide insight into the causes of inflammatory disease.
    Title: DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX24
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
DEAD box protein 24
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA helicase A)
NP_001152974.1
NP_001351091.1
NP_001351092.1
NP_065240.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159502.2 → NP_001152974.1  ATP-dependent RNA helicase DDX24 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154347, BB006411, BC055317
    Consensus CDS
    CCDS49152.1
    UniProtKB/TrEMBL
    F8WJA0, Q3U7R4
    Related
    ENSMUSP00000105628.3, ENSMUST00000110001.4
    Conserved Domains (3) summary
    COG0513
    Location:238 → 787
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:619 → 727
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:241 → 557
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001364162.1 → NP_001351091.1  ATP-dependent RNA helicase DDX24 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154347
    Consensus CDS
    CCDS26129.1
    UniProtKB/Swiss-Prot
    Q61119, Q7TM97, Q9ESV0
    UniProtKB/TrEMBL
    Q3U7R4
    Conserved Domains (1) summary
    COG0513
    Location:192 → 741
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  3. NM_001364163.1 → NP_001351092.1  ATP-dependent RNA helicase DDX24 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154347
    Consensus CDS
    CCDS26129.1
    UniProtKB/Swiss-Prot
    Q61119, Q7TM97, Q9ESV0
    UniProtKB/TrEMBL
    Q3U7R4
    Conserved Domains (1) summary
    COG0513
    Location:192 → 741
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  4. NM_020494.4 → NP_065240.2  ATP-dependent RNA helicase DDX24 isoform 2

    See identical proteins and their annotated locations for NP_065240.2

    Status: VALIDATED

    Source sequence(s)
    BB006411, BC043721, CJ141277
    Consensus CDS
    CCDS26129.1
    UniProtKB/Swiss-Prot
    Q61119, Q7TM97, Q9ESV0
    UniProtKB/TrEMBL
    Q3U7R4
    Related
    ENSMUSP00000040890.8, ENSMUST00000044923.15
    Conserved Domains (1) summary
    COG0513
    Location:192 → 741
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103374235..103392106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESV0.2 GenPept UniProtKB/Swiss-Prot:Q9ESV0

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