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ZC3H7A zinc finger CCCH-type containing 7A [ Homo sapiens (human) ]

Gene ID: 29066, updated on 27-Nov-2024

Summary

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Official Symbol
ZC3H7Aprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 7Aprovided by HGNC
Primary source
HGNC:HGNC:30959
See related
Ensembl:ENSG00000122299 MIM:619819; AllianceGenome:HGNC:30959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H7; HSPC055; ZC3HDC7
Summary
Enables miRNA binding activity. Involved in miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZC3H7A in Genome Data Viewer
Location:
16p13.13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11750597..11797258, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11786640..11833292, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11844453..11891114, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene stannin Neighboring gene thioredoxin domain containing 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10456 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11836693-11837215 Neighboring gene TXNDC11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene breast cancer anti-estrogen resistance 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene ribosomal L1 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of new high affinity targets for Roquin based on structural conservation. Braun J, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295819, Free PMC Article
  2. Common variants at ten loci influence QT interval duration in the QTGEN Study. Newton-Cheh C, et al. Nat Genet, 2009 Apr. PMID 19305408, Free PMC Article
  3. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. MacLeod G, et al. Cell Rep, 2019 Apr 16. PMID 30995489
  4. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B. Hunter MR, et al. J Mol Biol, 2018 Jul 6. PMID 29778605, Free PMC Article
  5. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Schmidt N, et al. Cell, 2023 Oct 26. PMID 37794589, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at ten loci influence QT interval duration in the QTGEN Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10027, FLJ20318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 7A
Names
zinc finger CCCH-type domain containing 7
zinc-finger protein AY163807

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014153.4 → NP_054872.2  zinc finger CCCH domain-containing protein 7A

    See identical proteins and their annotated locations for NP_054872.2

    Status: VALIDATED

    Source sequence(s)
    AY163807, BC046363, DA160892
    Consensus CDS
    CCDS10550.1
    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Related
    ENSP00000347999.4, ENST00000355758.9
    Conserved Domains (5) summary
    smart00356
    Location:906 → 926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44 → 119
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    11750597..11797258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522463.3 → XP_011520765.1  zinc finger CCCH domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_011520765.1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Conserved Domains (5) summary
    smart00356
    Location:906 → 926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44 → 119
    TPR_11; TPR repeat

  2. XM_047433996.1 → XP_047289952.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  3. XM_006720877.3 → XP_006720940.1  zinc finger CCCH domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_006720940.1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Conserved Domains (5) summary
    smart00356
    Location:906 → 926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44 → 119
    TPR_11; TPR repeat

  4. XM_017023174.2 → XP_016878663.1  zinc finger CCCH domain-containing protein 7A isoform X2

  5. XM_011522464.3 → XP_011520766.1  zinc finger CCCH domain-containing protein 7A isoform X4

    Conserved Domains (3) summary
    smart00356
    Location:667 → 687
    ZnF_C3H1; zinc finger
    sd00020
    Location:620 → 642
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:618 → 643
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  6. XM_047433998.1 → XP_047289954.1  zinc finger CCCH domain-containing protein 7A isoform X5

  7. XM_047433997.1 → XP_047289953.1  zinc finger CCCH domain-containing protein 7A isoform X3

    Related
    ENSP00000459747.1, ENST00000571198.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    11786640..11833292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380153.1 → XP_054236128.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  2. XM_054380155.1 → XP_054236130.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  3. XM_054380154.1 → XP_054236129.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  4. XM_054380156.1 → XP_054236131.1  zinc finger CCCH domain-containing protein 7A isoform X2

  5. XM_054380158.1 → XP_054236133.1  zinc finger CCCH domain-containing protein 7A isoform X4

  6. XM_054380159.1 → XP_054236134.1  zinc finger CCCH domain-containing protein 7A isoform X5

  7. XM_054380157.1 → XP_054236132.1  zinc finger CCCH domain-containing protein 7A isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWR0.1 GenPept UniProtKB/Swiss-Prot:Q8IWR0

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