U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prmt9 protein arginine methyltransferase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291947, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Prmt9provided by RGD
Official Full Name
protein arginine methyltransferase 9provided by RGD
Primary source
RGD:1306157
See related
EnsemblRapid:ENSRNOG00000012928 AllianceGenome:RGD:1306157
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prmt10; RGD1306157
Summary
Predicted to enable histone methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in chromatin remodeling; mRNA processing; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Orthologous to human PRMT9 (protein arginine methyltransferase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 121.1), Thymus (RPKM 119.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Prmt9 in Genome Data Viewer
Location:
19q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (47257974..47318719, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (30376342..30414491, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (34067008..34105626, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098594 Neighboring gene endothelin receptor type A Neighboring gene uncharacterized LOC134483343 Neighboring gene transmembrane protein 184C Neighboring gene Rho GTPase activating protein 10 Neighboring gene uncharacterized LOC134483344 Neighboring gene membrane-associated progesterone receptor component 1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. Hadjikyriacou A, et al. J Biol Chem, 2015 Jul 3. PMID 25979344, Free PMC Article
  2. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Yang Y, et al. Nat Commun, 2015 Mar 4. PMID 25737013, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein arginine N-methyltransferase 9
Names
protein arginine methyltransferase 10 (putative)
putative protein arginine N-methyltransferase 10
putative protein arginine N-methyltransferase 9
NP_001178528.1
XP_006255486.1
XP_063133967.1
XP_063133968.1
XP_063133969.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191599.1 → NP_001178528.1  protein arginine N-methyltransferase 9

    See identical proteins and their annotated locations for NP_001178528.1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I6AMT6, D3ZDR5
    Related
    ENSRNOP00000017347.6, ENSRNOT00000017347.9
    Conserved Domains (3) summary
    sd00006
    Location:68 → 95
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:68 → 132
    TPR_11; TPR repeat
    cl17173
    Location:148 → 338
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    47257974..47318719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255424.5 → XP_006255486.1  protein arginine N-methyltransferase 9 isoform X1

    See identical proteins and their annotated locations for XP_006255486.1

    UniProtKB/TrEMBL
    A0A8I6AMT6, D3ZDR5
    Conserved Domains (3) summary
    sd00006
    Location:68 → 95
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:68 → 132
    TPR_11; TPR repeat
    cl17173
    Location:148 → 338
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_063277897.1 → XP_063133967.1  protein arginine N-methyltransferase 9 isoform X2

  3. XM_063277898.1 → XP_063133968.1  protein arginine N-methyltransferase 9 isoform X3

    UniProtKB/TrEMBL
    A6IYK7

  4. XM_063277899.1 → XP_063133969.1  protein arginine N-methyltransferase 9 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools