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Unc5cl unc-5 family C-terminal like [ Rattus norvegicus (Norway rat) ]

Gene ID: 301225, updated on 27-Nov-2024

Summary

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Official Symbol
Unc5clprovided by RGD
Official Full Name
unc-5 family C-terminal likeprovided by RGD
Primary source
RGD:1587368
See related
EnsemblRapid:ENSRNOG00000046601 AllianceGenome:RGD:1587368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable peptidase activity. Predicted to be involved in positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. Orthologous to human UNC5CL (unc-5 family C-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 65.3), Liver (RPKM 17.8) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Unc5cl in Genome Data Viewer
Location:
9q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20025719..20041083, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (12528109..12543382, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (14494080..14510302, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547840 Neighboring gene uncharacterized LOC102548200 Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene O-acyl-ADP-ribose deacylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Heinz LX, et al. Cell Death Differ, 2012 Apr. PMID 22158417, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables netrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UNC5C-like protein
Names
unc-5 homolog C-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106882.3 → NP_001100352.2  UNC5C-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A096MKD8
    Related
    ENSRNOP00000068477.1, ENSRNOT00000076531.3
    Conserved Domains (3) summary
    pfam00791
    Location:108 → 185
    ZU5; ZU5 domain
    pfam17217
    Location:243 → 346
    UPA; UPA domain
    cl14633
    Location:408 → 488
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. NM_001431992.1 → NP_001418921.1  UNC5C-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RNA

  1. NR_197263.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    20025719..20041083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244422.4 → XP_006244484.1  UNC5C-like protein isoform X1

    See identical proteins and their annotated locations for XP_006244484.1

    UniProtKB/TrEMBL
    A0A096MKD8
    Conserved Domains (3) summary
    pfam00791
    Location:108 → 185
    ZU5; ZU5 domain
    pfam17217
    Location:243 → 346
    UPA; UPA domain
    cl14633
    Location:408 → 488
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_063266843.1 → XP_063122913.1  UNC5C-like protein isoform X1

    UniProtKB/TrEMBL
    A0A096MKD8

  3. XM_006244423.5 → XP_006244485.1  UNC5C-like protein isoform X2

    Conserved Domains (2) summary
    pfam00791
    Location:103 → 185
    ZU5; ZU5 domain
    cl14633
    Location:408 → 445
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_063266842.1 → XP_063122912.1  UNC5C-like protein isoform X1

  5. XM_039083172.1 → XP_038939100.1  UNC5C-like protein isoform X3

    Conserved Domains (2) summary
    pfam17217
    Location:4 → 105
    UPA; UPA domain
    cl14633
    Location:158 → 238
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_005488861.2 RNA Sequence

  2. XR_005488862.2 RNA Sequence

  3. XR_005488863.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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