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Klhl5 kelch-like family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305351, updated on 4-Jan-2025

Summary

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Official Symbol
Klhl5provided by RGD
Official Full Name
kelch-like family member 5provided by RGD
Primary source
RGD:1309661
See related
EnsemblRapid:ENSRNOG00000008421 AllianceGenome:RGD:1309661
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human KLHL5 (kelch like family member 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 219.9), Spleen (RPKM 141.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl5 in Genome Data Viewer
Location:
14p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43497915..43565833, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (43144254..43206192, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44805213..44867075, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 12 Neighboring gene solute carrier family 25, member 51 like 1 Neighboring gene uncharacterized LOC102556650 Neighboring gene transmembrane protein 156 Neighboring gene family with sequence similarity 114, member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 5
Names
kelch-like 5
myocardial ischemic preconditioning associated protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047093.1 → NP_001040558.1  kelch-like protein 5

    See identical proteins and their annotated locations for NP_001040558.1

    Status: PROVISIONAL

    Source sequence(s)
    AY641809
    UniProtKB/TrEMBL
    A0A8I6AAB1, Q1EG90
    Related
    ENSRNOP00000004003.4, ENSRNOT00000004003.9
    Conserved Domains (6) summary
    smart00612
    Location:562 → 608
    Kelch; Kelch domain
    PHA03098
    Location:173 → 695
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:457 → 500
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:163 → 266
    BTB; BTB/POZ domain
    pfam01344
    Location:456 → 501
    Kelch_1; Kelch motif
    pfam07707
    Location:275 → 374
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    43497915..43565833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250959.5 → XP_006251021.1  kelch-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006251021.1

    UniProtKB/TrEMBL
    A0A8I6AAT7
    Conserved Domains (6) summary
    smart00612
    Location:422 → 468
    Kelch; Kelch domain
    PHA03098
    Location:33 → 555
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:317 → 360
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:23 → 126
    BTB; BTB/POZ domain
    pfam01344
    Location:316 → 361
    Kelch_1; Kelch motif
    pfam07707
    Location:135 → 234
    BACK; BTB And C-terminal Kelch

  2. XM_039091924.2 → XP_038947852.1  kelch-like protein 5 isoform X2

    Conserved Domains (3) summary
    PHA03098
    Location:7 → 429
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:191 → 234
    Kelch; KELCH repeat [structural motif]
    cd18511
    Location:3 → 108
    BACK_KLHL5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5)

  3. XM_039091923.2 → XP_038947851.1  kelch-like protein 5 isoform X3

    Conserved Domains (2) summary
    cl38908
    Location:150 → 279
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:269 → 370
    BACK; BACK (BTB and C-terminal Kelch) domain
Nucleotide Protein Strain
Heading Accession and Version

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