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Tsp3A Tetraspanin 3A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31244, updated on 9-Dec-2024

Summary

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Official Symbol
Tsp3Aprovided by FlyBase
Official Full Name
Tetraspanin 3Aprovided by FlyBase
Primary source
FLYBASE:FBgn0040334
Locus tag
Dmel_CG10742
See related
AllianceGenome:FB:FBgn0040334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BACR7C10.6; CG10742; Dm.Tsp3A; Dmel\CG10742; EG:BACR7C10.6; tsp3A
Summary
Involved in intracellular protein transport and positive regulation of Notch signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including TSPAN33 (tetraspanin 33). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Tsp3A in Genome Data Viewer
Location:
3A7-3A7; 1-1 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2617758..2619738, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2511791..2513771, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Zeste-white 10 Neighboring gene SET and MYND domain containing, class 3 Neighboring gene eukaryotic translation initiation factor 3 subunit g1 Neighboring gene seipin Neighboring gene Phosphatidylinositol 4-kinase III alpha Neighboring gene brivido-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context. Kemppainen E, et al. Mitochondrion, 2009 Sep. PMID 19616644
  2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
  3. Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway. Johns AR, et al. G3 (Bethesda), 2018 Mar 2. PMID 29363515, Free PMC Article
  4. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
  5. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin 3A
Names
CG10742-PA
CG10742-PB
Tsp3A-PA
Tsp3A-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2617758..2619738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258575.1 → NP_001245504.1  tetraspanin 3A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245504.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1L0, Q9W4X6
    Conserved Domains (2) summary
    cd03158
    Location:144 → 267
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:42 → 295
    Tetraspannin; Tetraspanin family

  2. NM_080315.3 → NP_525054.2  tetraspanin 3A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525054.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1L0, Q9W4X6
    Related
    FBpp0070429
    Conserved Domains (2) summary
    cd03158
    Location:144 → 267
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:42 → 295
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NB16 Q9NB16
Q9U1L0 Q9U1L0
Q9W4X6 Q9W4X6

Gene LinkOut

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