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Plekhg3 pleckstrin homology and RhoGEF domain containing G3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314249, updated on 27-Nov-2024

Summary

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Official Symbol
Plekhg3provided by RGD
Official Full Name
pleckstrin homology and RhoGEF domain containing G3provided by RGD
Primary source
RGD:1308089
See related
EnsemblRapid:ENSRNOG00000006570 AllianceGenome:RGD:1308089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308089
Summary
Predicted to enable actin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in regulation of cell migration and regulation of establishment of cell polarity. Orthologous to human PLEKHG3 (pleckstrin homology and RhoGEF domain containing G3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 106.0), Brain (RPKM 45.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekhg3 in Genome Data Viewer
Location:
6q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (100998965..101042120)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95265756..95308952)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99612993..99655753)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556012 Neighboring gene ribosomal protein S17 like 1 Neighboring gene spectrin, beta, erythrocytic Neighboring gene uncharacterized LOC134479402

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology and RhoGEF domain containing G3; pleckstrin homology domain-containing family G member 3
Names
pleckstrin homology domain containing, family G (with RhoGef domain) member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431908.1 → NP_001418837.1  pleckstrin homology and RhoGEF domain containing G3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6ATN8

  2. NM_001431909.1 → NP_001418838.1  pleckstrin homology and RhoGEF domain containing G3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    100998965..101042120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594466.3 → XP_017449955.1  pleckstrin homology domain-containing family G member 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A394
    Conserved Domains (2) summary
    cd13243
    Location:253 → 396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:97 → 270
    RhoGEF; RhoGEF domain

  2. XM_063262762.1 → XP_063118832.1  pleckstrin homology domain-containing family G member 3 isoform X8

    Related
    ENSRNOP00000097983.2, ENSRNOT00000105013.2

  3. XM_063262765.1 → XP_063118835.1  pleckstrin homology domain-containing family G member 3 isoform X11

  4. XM_063262763.1 → XP_063118833.1  pleckstrin homology domain-containing family G member 3 isoform X9

    Related
    ENSRNOP00000108696.1, ENSRNOT00000156659.1

  5. XM_063262766.1 → XP_063118836.1  pleckstrin homology domain-containing family G member 3 isoform X12

  6. XM_017594469.3 → XP_017449958.2  pleckstrin homology domain-containing family G member 3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A394
    Conserved Domains (2) summary
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 291
    RhoGEF; RhoGEF domain

  7. XM_017594465.3 → XP_017449954.1  pleckstrin homology domain-containing family G member 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A394

  8. XM_017594464.3 → XP_017449953.2  pleckstrin homology domain-containing family G member 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A394
    Conserved Domains (2) summary
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 291
    RhoGEF; RhoGEF domain

  9. XM_017594471.3 → XP_017449960.2  pleckstrin homology domain-containing family G member 3 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A394
    Conserved Domains (2) summary
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 291
    RhoGEF; RhoGEF domain

  10. XM_063262761.1 → XP_063118831.1  pleckstrin homology domain-containing family G member 3 isoform X3

  11. XM_039113273.2 → XP_038969201.1  pleckstrin homology domain-containing family G member 3 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A394
    Conserved Domains (2) summary
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 291
    RhoGEF; RhoGEF domain

  12. XM_063262764.1 → XP_063118834.1  pleckstrin homology domain-containing family G member 3 isoform X10

  13. XM_017594472.3 → XP_017449961.2  pleckstrin homology domain-containing family G member 3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A394, D3ZA21
    Related
    ENSRNOP00000008573.6, ENSRNOT00000008573.9
    Conserved Domains (2) summary
    cd13243
    Location:274 → 417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 291
    RhoGEF; RhoGEF domain

  14. XM_017594473.3 → XP_017449962.1  pleckstrin homology domain-containing family G member 3 isoform X13

    UniProtKB/TrEMBL
    A0A8I6A394
Nucleotide Protein Strain
Heading Accession and Version

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