U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nxf3 Nuclear export factor 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317878, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Nxf3provided by FlyBase
Official Full Name
Nuclear export factor 3provided by FlyBase
Primary source
FLYBASE:FBgn0263232
Locus tag
Dmel_CG32135
See related
AllianceGenome:FB:FBgn0263232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32135; Dmel\CG32135; nxf3; NXF3
Summary
Predicted to enable RNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in nucleus. Orthologous to human NXF1 (nuclear RNA export factor 1); NXF2 (nuclear RNA export factor 2); and NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nxf3 in Genome Data Viewer
Location:
70C7-70C9; 3-41 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13965203..13973067)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13958303..13966167)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Meiotic central spindle Neighboring gene short spindle 2 Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 70 cognate 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes. Głuszek AA, et al. J Cell Biol, 2015 Dec 21. PMID 26668329, Free PMC Article
  2. Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis. Lin Y, et al. J Cell Biol, 2023 Oct 2. PMID 37555815, Free PMC Article
  3. To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma. Wang S, et al. Biochem Soc Trans, 2021 Nov 1. PMID 34643228
  4. The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters. Baumgartner L, et al. Elife, 2022 Oct 4. PMID 36193674, Free PMC Article
  5. TEMPLE: analysing population genetic variation at transcription factor binding sites. Litovchenko M, et al. Mol Ecol Resour, 2016 Nov. PMID 27106869

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nxf3 promotes export of piRNA cluster transcripts to cytoplasmic processing sites
    Title: Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

  • transcript and protein products are distinct from overlapping gene

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear export factor 3
Names
CG32135-PD
CG32135-PE
Nxf3-PD
Nxf3-PE

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13965203..13973067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300135.1 → NP_001287064.2  nuclear export factor 3, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW3, Q8IQK4
    Conserved Domains (3) summary
    sd00035
    Location:191 → 231
    LRR_NTF; leucine-rich repeat [structural motif]
    cd21340
    Location:192 → 296
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl09109
    Location:338 → 489
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  2. NM_168566.2 → NP_729938.2  nuclear export factor 3, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW3, Q8IQK4
    Conserved Domains (3) summary
    sd00035
    Location:191 → 231
    LRR_NTF; leucine-rich repeat [structural motif]
    cd21340
    Location:192 → 296
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl09109
    Location:338 → 489
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQK4 Q8IQK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.