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Efhc1.1 EF-hand domain containing 1.1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32528, updated on 4-Jan-2025

Summary

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Official Symbol
Efhc1.1provided by FlyBase
Official Full Name
EF-hand domain containing 1.1provided by FlyBase
Primary source
FLYBASE:FBgn0030691
Locus tag
Dmel_CG8959
See related
AllianceGenome:FB:FBgn0030691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8959; Dmel\CG8959
Summary
Involved in regulation of dendrite morphogenesis and synaptic assembly at neuromuscular junction. Located in dendrite; neuronal cell body; and terminal bouton. Colocalizes with microtubule. Is expressed in adult head and spermatozoon. Orthologous to human EFHC2 (EF-hand domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Efhc1.1 in Genome Data Viewer
Location:
13E17-13E18; 1-51 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15780398..15783710, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15674431..15677743, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Platelet-activating factor acetylhydrolase alpha Neighboring gene mitochondrial ribosomal protein S30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defhc1.1, a homologue of the juvenile myoclonic gene EFHC1, modulates architecture and basal activity of the neuromuscular junction in Drosophila. Rossetto MG, et al. Hum Mol Genet, 2011 Nov 1. PMID 21835885
  2. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm. Ramesh R, et al. Antioxid Redox Signal, 2023 Jun. PMID 36509450, Free PMC Article
  3. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489
  4. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
EF-hand domain containing 1.1
Names
CG8959-PA
Defhc1.1
EFHC1 homolog
EFHC1 homologue 1
Efhc1.1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15780398..15783710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132847.2 → NP_573075.1  EF-hand domain containing 1.1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C543, Q9VXP5
    Related
    FBpp0073977
    Conserved Domains (2) summary
    smart00676
    Location:82 → 189
    DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
    pfam06565
    Location:110 → 142
    DUF1126; Repeat of unknown function (DUF1126)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXP5 Q9VXP5

Gene LinkOut

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