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tau tau [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326116, updated on 9-Dec-2024

Summary

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Official Symbol
tauprovided by FlyBase
Official Full Name
tauprovided by FlyBase
Primary source
FLYBASE:FBgn0266579
Locus tag
Dmel_CG45110
See related
AllianceGenome:FB:FBgn0266579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE16764; CG12881; CG31057; CG31058; CG34294; CG45110; CG5606; d-tau; Dmel\CG45110; dtau; dTau; dTAU; tao; Tau
Old locus tag
Dmel_CG31057; Dmel_CG31058; Dmel_CG34294
Summary
Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; open tracheal system development; and rhabdomere morphogenesis. Located in axon and dendrite. Colocalizes with cytoplasmic microtubule. Is expressed in several structures, including brain; chordotonal organ; head; imaginal disc; and synaptic neuropil domain. Used to study Pick's disease; amnestic disorder; frontotemporal dementia; neurodegenerative disease; and tauopathy. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See tau in Genome Data Viewer
Location:
98A13-98A14; 3-94 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27639886..27656996, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23465608..23482718, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tusp Neighboring gene uncharacterized protein Neighboring gene Mig-2-like Neighboring gene mir-1001 stem loop Neighboring gene Ribosomal protein S10a Neighboring gene Myosin alkali light chain 1 Neighboring gene uncoordinated 80

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of high-fat diet-induced miRNA ameliorates tau toxicity in Drosophila. Singh MK, et al. Biochem Biophys Res Commun, 2024 Nov 12. PMID 39067249
  2. Quantitative characterization of adhesion and stiffness of corneal lens of Drosophila melanogaster using atomic force microscopy. Lavanya Devi AL, et al. J Mech Behav Biomed Mater, 2016 Jan. PMID 26327451
  3. Drosophila appear resistant to trans-synaptic tau propagation. Catterson JH, et al. Brain Commun, 2024. PMID 39130515, Free PMC Article
  4. Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila. Talmat-Amar Y, et al. Int J Mol Sci, 2018 Mar 6. PMID 29509687, Free PMC Article
  5. Moderate Overexpression of Tau in Drosophila Exacerbates Amyloid-β-Induced Neuronal Phenotypes and Correlates with Tau Oligomerization. Miguel L, et al. J Alzheimers Dis, 2020. PMID 32065789

See all (192) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of high-fat diet-induced miRNA ameliorates tau toxicity in Drosophila.
    Title: Inhibition of high-fat diet-induced miRNA ameliorates tau toxicity in Drosophila.
  2. Tau suppresses microtubule-regulated pancreatic insulin secretion.
    Title: Tau suppresses microtubule-regulated pancreatic insulin secretion.
  3. Mical modulates Tau toxicity via cysteine oxidation in vivo.
    Title: Mical modulates Tau toxicity via cysteine oxidation in vivo.
  4. Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    Title: Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
  5. Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells.
    Title: Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells.
  6. Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.
    Title: Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.
  7. We demonstrate that despite modest sequence divergence, the Drosophila tau (dTau) is a true vertebrate tau ortholog as it interacts with the neuronal microtubule and actin cytoskeleton. Novel physiological roles for dTau in regulation of translation, long-term memory, and footshock habituation are also revealed.
    Title: Drosophila Tau Negatively Regulates Translation and Olfactory Long-Term Memory, But Facilitates Footshock Habituation and Cytoskeletal Homeostasis.
  8. polyadenylated RNAs accumulate within and adjacent to tau-induced nuclear envelope invaginations in a Drosophila model of tauopathy.
    Title: Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila.
  9. Our collective data demonstrate the complexity of 14-3-3/Tau interactions in vivo and suggest that 14-3-3 attenuation is not appropriate ameliorative treatment of Tauopathies. Finally, we suggest that 'bystander' 14-3-3s are recruited by accumulating Tau with the consequences depending on the composition of available dimers within particular neurons and the Tau variant.
    Title: Differential effects of 14-3-3 dimers on Tau phosphorylation, stability and toxicity in vivo.
  10. The comprehensive pathological and molecular data generated through this study strongly validate the causal role of TREM2/TYROBP in driving molecular networks in Alzheimer's disease (AD) and AD-related phenotypes in flies.[
    Title: Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in branching involved in open tracheal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lumen formation, open tracheal system IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhabdomere morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tau
Names
CG45110-PA
CG45110-PB
CG45110-PC
CG45110-PE
CG45110-PF
CG45110-PG
CG45110-PH
CG45110-PI
CG45110-PJ
CG45110-PK
CG45110-PL
CG45110-PM
CG45110-PN
CG45110-PO
tau-PA
tau-PB
tau-PC
tau-PE
tau-PF
tau-PG
tau-PH
tau-PI
tau-PJ
tau-PK
tau-PL
tau-PM
tau-PN
tau-PO

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27639886..27656996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300635.1 → NP_001287564.1  tau, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287564.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHR7
    Conserved Domains (1) summary
    pfam00418
    Location:165 → 195
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  2. NM_001300636.1 → NP_001287565.1  tau, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHS3
    Conserved Domains (1) summary
    pfam00418
    Location:257 → 286
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  3. NM_001300634.1 → NP_001287563.1  tau, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287563.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIS6
    Conserved Domains (1) summary
    pfam00418
    Location:288 → 316
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  4. NM_001276088.1 → NP_001263017.1  tau, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UT1, Q9VB13
    Conserved Domains (1) summary
    pfam00418
    Location:288 → 316
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  5. NM_001276090.2 → NP_001263019.2  tau, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263019.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI45
    Conserved Domains (1) summary
    pfam00418
    Location:257 → 286
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  6. NM_143318.3 → NP_651575.1  tau, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651575.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UT1, Q9VB13
    Related
    FBpp0311073
    Conserved Domains (1) summary
    pfam00418
    Location:288 → 316
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  7. NM_001276089.1 → NP_001263018.1  tau, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHQ8
    Conserved Domains (1) summary
    pfam00418
    Location:288 → 316
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  8. NM_001316620.1 → NP_001303549.1  tau, isoform N [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GV16
    Conserved Domains (1) summary
    pfam00418
    Location:288 → 316
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  9. NM_001300639.1 → NP_001287568.1  tau, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287568.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIT4
    Conserved Domains (1) summary
    pfam00418
    Location:296 → 322
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  10. NM_001382126.1 → NP_001369032.1  tau, isoform O [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EDU2

  11. NM_170345.3 → NP_733224.2  tau, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733224.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VB15
    Conserved Domains (1) summary
    pfam00418
    Location:644 → 672
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  12. NM_001300637.1 → NP_001287566.1  tau, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287566.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHV0
    Conserved Domains (2) summary
    PHA03309
    Location:15 → 88
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:205 → 233
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  13. NM_001300638.1 → NP_001287567.1  tau, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHV0
    Conserved Domains (2) summary
    PHA03309
    Location:15 → 88
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:205 → 233
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  14. NM_001276091.1 → NP_001263020.1  tau, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263020.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMW4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHQ8 A0A0B4KHQ8
A0A0B4KI45 A0A0B4KI45
A0A0B4LHR7 A0A0B4LHR7
A0A0B4LHS3 A0A0B4LHS3
A0A0B4LHV0 A0A0B4LHV0
A0A0B4LIS6 A0A0B4LIS6
A0A0B4LIT4 A0A0B4LIT4
A0A126GV16 A0A126GV16
A0A6H2EDU2 A0A6H2EDU2
D3DMW4 D3DMW4
Q9VB13 Q9VB13
Q9VB15 Q9VB15

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