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Zfp335 zinc finger protein 335 [ Mus musculus (house mouse) ]

Gene ID: 329559, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp335provided by MGI
Official Full Name
zinc finger protein 335provided by MGI
Primary source
MGI:MGI:2682313
See related
Ensembl:ENSMUSG00000039834 AllianceGenome:MGI:2682313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nif1; NIF-1; Znf335; 1810045J01Rik
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone methyltransferase binding activity. Involved in brain development; neuron projection morphogenesis; and positive regulation of neuroblast proliferation. Acts upstream of or within several processes, including brain development; in utero embryonic development; and regulation of neurogenesis. Located in nucleus. Part of histone methyltransferase complex. Is expressed in brain and future brain. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 31.4), spleen adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp335 in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164733802..164756034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164891882..164912585, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6019 Neighboring gene STARR-positive B cell enhancer ABC_E2059 Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene predicted gene, 46775 Neighboring gene STARR-seq mESC enhancer starr_06342 Neighboring gene zinc finger protein 335, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164764412-164764521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164768440-164768694 Neighboring gene matrix metallopeptidase 9 Neighboring gene solute carrier family 12, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1. Liu H, et al. J Immunol, 2022 Sep 1. PMID 35914836
  2. The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression. Liu H, et al. J Immunol, 2024 Jun 1. PMID 38598411
  3. Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms. Wang X, et al. Elife, 2022 Feb 3. PMID 35113015, Free PMC Article
  4. NRC-interacting factor directs neurite outgrowth in an activity-dependent manner. Zhao XS, et al. Neuroscience, 2015 Mar 19. PMID 25573434
  5. Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation. Wang X, et al. J Clin Invest, 2023 Oct 16. PMID 37843279, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression.
    Title: The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression.
  2. Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.
    Title: Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation.
  3. The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.
    Title: The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1.
  4. p35 interacts with NIF-1 and regulates the subcellular localization of the protein independent of Cdk5-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5
    Title: p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).
  5. Results suggest that NIF-1 directs neuronal morphogenesis during early developmental stages through modulating activity-dependent gene transcription
    Title: NRC-interacting factor directs neurite outgrowth in an activity-dependent manner.
  6. Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment.
    Title: Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.
  7. Znf335 null mice are embryonically lethal, and conditional knockout leads to severely reduced cortical size.
    Title: Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Transgenic (1) 

General gene information

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Homology

Clone Names

  • MGC86001

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebral cortex neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epigenetic regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lymphocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 335
Names
NRC-interacting factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199027.2 → NP_950192.2  zinc finger protein 335

    See identical proteins and their annotated locations for NP_950192.2

    Status: VALIDATED

    Source sequence(s)
    BC062921, CN721033
    Consensus CDS
    CCDS38331.1
    UniProtKB/Swiss-Prot
    A2A5K6, B2RXR9, Q3TZT1
    Related
    ENSMUSP00000038298.8, ENSMUST00000041361.14
    Conserved Domains (4) summary
    COG5189
    Location:1026 → 1126
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:1049 → 1069
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1089 → 1114
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1075 → 1099
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164733802..164756034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251805.2 → XP_030107665.1  zinc finger protein 335 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:1027 → 1127
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:1050 → 1070
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1090 → 1115
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1076 → 1100
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_030251807.2 → XP_030107667.1  zinc finger protein 335 isoform X2

    UniProtKB/Swiss-Prot
    A2A5K6, B2RXR9, Q3TZT1
    Conserved Domains (4) summary
    COG5189
    Location:1026 → 1126
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:1049 → 1069
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1089 → 1114
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1075 → 1099
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. XM_030251806.2 → XP_030107666.1  zinc finger protein 335 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:1027 → 1127
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:1050 → 1070
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1090 → 1115
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1076 → 1100
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_036162334.1 → XP_036018227.1  zinc finger protein 335 isoform X2

    UniProtKB/Swiss-Prot
    A2A5K6, B2RXR9, Q3TZT1
    Conserved Domains (4) summary
    COG5189
    Location:1026 → 1126
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:1049 → 1069
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1089 → 1114
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1075 → 1099
    zf-H2C2_5; C2H2-type zinc-finger domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A5K6.1 GenPept UniProtKB/Swiss-Prot:A2A5K6

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