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Tspo Translocator protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33231, updated on 9-Dec-2024

Summary

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Official Symbol
Tspoprovided by FlyBase
Official Full Name
Translocator proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031263
Locus tag
Dmel_CG2789
See related
AllianceGenome:FB:FBgn0031263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey116; CG2789; Dmel\CG2789; dTSPO; tspo
Summary
Involved in determination of adult lifespan; positive regulation of apoptotic process; and regulation of oxidative phosphorylation. Located in mitochondrial outer membrane. Is expressed in adult head and organism. Orthologous to several human genes including TSPO (translocator protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Tspo in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (559612..560523)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (559612..560523)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor beta3 Neighboring gene Signal peptide peptidase Neighboring gene Ets at 21C Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene uncharacterized protein Neighboring gene Notchless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. Lin R, et al. Aging Cell, 2014 Jun. PMID 24977274, Free PMC Article
  2. Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila. Jullian E, et al. Biochimie, 2024 Sep. PMID 38750879
  3. TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila. Lin R, et al. PLoS Genet, 2015 Aug. PMID 26241038, Free PMC Article
  4. Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila. Cho JH, et al. Biochem Biophys Res Commun, 2015 Jul 17-24. PMID 25979357
  5. An IFT-A protein is required to delimit functionally distinct zones in mechanosensory cilia. Lee E, et al. Curr Biol, 2008 Dec 23. PMID 19097904, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila.
    Title: Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila.
  2. Mitochondrial TSPO function plays an important role in ethanol sensitivity and tolerance.
    Title: TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translocator protein
Names
CG2789-PA
Tspo-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    559612..560523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134687.4 → NP_608531.1  translocator protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608531.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPR1
    Related
    FBpp0077726
    Conserved Domains (1) summary
    pfam03073
    Location:17 → 161
    TspO_MBR; TspO/MBR family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPR1 Q9VPR1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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