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Sec24CD Secretory 24CD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33409, updated on 9-Dec-2024

Summary

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Official Symbol
Sec24CDprovided by FlyBase
Official Full Name
Secretory 24CDprovided by FlyBase
Primary source
FLYBASE:FBgn0262126
Locus tag
Dmel_CG10882
See related
AllianceGenome:FB:FBgn0262126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LP05220; CG10882; Dmel\CG10882; FBgn0031408; gho; Gho; sec24; Sec24; sfb3; sten; Sten
Summary
Predicted to enable SNARE binding activity and zinc ion binding activity. Involved in several processes, including protein localization to cell surface; regulation of tube diameter, open tracheal system; and secretion by cell. Acts upstream of with a positive effect on chitin-based cuticle development and lumen formation, open tracheal system. Located in endoplasmic reticulum exit site. Part of COPII vesicle coat. Is expressed in several structures, including circulatory system primordium; embryonic/larval midgut primordium; epithelium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including SEC24D (SEC24 homolog D, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sec24CD in Genome Data Viewer
Location:
22D4-22D5; 2-5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2231106..2236844, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2231106..2236844, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44114 Neighboring gene sauron Neighboring gene antisense RNA:CR44115 Neighboring gene Testis EndoG-Like 3 Neighboring gene Testis EndoG-Like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export. Kumichel A, et al. Traffic, 2015 Jun. PMID 25753515, Free PMC Article
  2. Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila. Iyer SC, et al. J Cell Sci, 2013 Oct 15. PMID 23902691, Free PMC Article
  3. The apical plasma membrane of chitin-synthesizing epithelia. Moussian B. Insect Sci, 2013 Apr. PMID 23955854
  4. Drosophila Embryos as a Model for Wound-Induced Transcriptional Dynamics: Genetic Strategies to Achieve a Localized Wound Response. Juarez MT. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274436, Free PMC Article
  5. Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation. Norum M, et al. PLoS One, 2010 May 24. PMID 20520821, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII-coated vesicle cargo loading ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_positive_effect chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_positive_effect lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube diameter, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
part_of COPII vesicle coat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of COPII vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secretory 24CD
Names
CG10882-PA
CG10882-PB
CG10882-PC
Sec24CD ortholog
Sec24CD-PA
Sec24CD-PB
Sec24CD-PC
ghost
stenosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2231106..2236844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272988.1 → NP_001259917.1  secretory 24CD, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259917.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960I6, Q9VQ94
    Conserved Domains (6) summary
    COG5028
    Location:395 → 1190
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:599 → 847
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:1061 → 1135
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:522 → 559
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:950 → 1043
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:848 → 932
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  2. NM_001272989.1 → NP_001259918.1  secretory 24CD, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259918.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC99
    Conserved Domains (6) summary
    COG5028
    Location:395 → 1190
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:599 → 847
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:1061 → 1135
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:522 → 559
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:950 → 1043
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:848 → 932
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  3. NM_134820.3 → NP_608664.2  secretory 24CD, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608664.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960I6, Q9VQ94
    Related
    FBpp0077487
    Conserved Domains (6) summary
    COG5028
    Location:395 → 1190
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:599 → 847
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:1061 → 1135
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:522 → 559
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:950 → 1043
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:848 → 932
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PC99 M9PC99
Q9VQ94 Q9VQ94

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