Dbp80 Dead box protein 80 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dbp80provided by FlyBase
Official Full Name: Dead box protein 80provided by FlyBase
Primary source: FLYBASE:FBgn0024804
Locus tag: Dmel_CG17023
See related: AllianceGenome:FB:FBgn0024804
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE44177; CG17023; dbp-80; dbp80; DBP80; DDX19; DmDbp80; Dmel\CG17023; hel-40; Hel40; Hel80; HEL80; mdcds_36124
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasmic stress granule and nucleus. Is expressed in adult head; embryonic brain; and organism. Orthologous to several human genes including DDX19A (DEAD-box helicase 19A) and DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 80F9-80F9; 3-47 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (27279316..27422159)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3LHet	NW_001848857.1 (2409852..2545146)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study shows that Dbp80 and RpL15 can function in contrasting chromatin contexts on an evolutionary timescale. The complex history of these genes also provides unique insight into the dynamic nature of genome evolution.
Title: Heterochromatic genes in Drosophila: a comparative analysis of two genes.
RpL15 is uncharacteristically small, highly expressed, and encodes an essential ribosomal protein; its expression appears to be compromised in a genetic background deficient for heterochromatin protein 1
Title: A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 27389275-27390321 mobile_element_type = transposon:1360{}6388

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore cytoplasmic filaments	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dead box protein 80

Names: CG17023-PB; CG17023-PD; CG17023-PE; CG17023-PF; CG17023-PG; Dbp80-PB; Dbp80-PD; Dbp80-PE; Dbp80-PF; Dbp80-PG; helicase 40; helicase 80

NP_001015151.1

EC 3.6.4.13

NP_001015152.2

EC 3.6.4.13

NP_001263168.1

EC 3.6.4.13

NP_001263169.1

EC 3.6.4.13

NP_001263170.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

27279316..27422159

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276241.1 → NP_001263170.1 dead box protein 80, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263170.1

Status: REVIEWED

UniProtKB/TrEMBL

L7EFC0

Conserved Domains (2) summary

smart00487
Location:88 → 291

DEXDc; DEAD-like helicases superfamily

cd00268
Location:75 → 277

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001276239.1 → NP_001263168.1 dead box protein 80, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263168.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61305

UniProtKB/TrEMBL

L7EEU0

Conserved Domains (3) summary

smart00487
Location:88 → 291

DEXDc; DEAD-like helicases superfamily

cd00268
Location:75 → 277

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:299 → 414

Helicase_C; Helicase conserved C-terminal domain
NM_001276240.1 → NP_001263169.1 dead box protein 80, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263169.1

Status: REVIEWED

UniProtKB/TrEMBL

G7H860, L7EGI4

Conserved Domains (3) summary

COG0513
Location:28 → 249

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

pfam00271
Location:134 → 249

Helicase_C; Helicase conserved C-terminal domain

cl21455
Location:4 → 112

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001015151.3 → NP_001015151.1 dead box protein 80, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015151.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61305

UniProtKB/TrEMBL

Q5LK13

Conserved Domains (3) summary

smart00487
Location:88 → 291

DEXDc; DEAD-like helicases superfamily

cd00268
Location:75 → 277

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:299 → 415

Helicase_C; Helicase conserved C-terminal domain
NM_001015152.4 → NP_001015152.2 dead box protein 80, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015152.2

Status: REVIEWED

UniProtKB/TrEMBL

Q5LK12, Q8SYQ3

Conserved Domains (2) summary

smart00487
Location:88 → 278

DEXDc; DEAD-like helicases superfamily

cd00268
Location:75 → 277

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...