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tctn tectonic [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33866, updated on 9-Dec-2024

Summary

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Official Symbol
tctnprovided by FlyBase
Official Full Name
tectonicprovided by FlyBase
Primary source
FLYBASE:FBgn0261697
Locus tag
Dmel_CG42731
See related
AllianceGenome:FB:FBgn0261697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG42731; CG9227; Dmel\CG42731; Tectonic
Old locus tag
Dmel_CG9227
Summary
Involved in sperm axoneme assembly. Located in ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome 13; Joubert syndrome 18; and orofaciodigital syndrome IV. Orthologous to human TCTN1 (tectonic family member 1) and TCTN3 (tectonic family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See tctn in Genome Data Viewer
Location:
26B7-26B8; 2-18 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6127872..6130651, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6127872..6130651, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene stathmin Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2/3 complex, subunit 4 Neighboring gene WD repeat domain 79 Neighboring gene B9d2 Neighboring gene long non-coding RNA:CR45719 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells. Vieillard J, et al. J Cell Biol, 2016 Sep 26. PMID 27646273, Free PMC Article
  2. Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults. Pratt MB, et al. J Cell Sci, 2016 Oct 15. PMID 27577095, Free PMC Article
  3. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
  4. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Reiter JF, et al. Genes Dev, 2006 Jan 1. PMID 16357211, Free PMC Article
  5. Systematic analysis of the transcriptional switch inducing migration of border cells. Borghese L, et al. Dev Cell, 2006 Apr. PMID 16580994, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MKS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
tectonic
Names
CG42731-PA
tctn-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6127872..6130651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135154.3 → NP_608998.2  tectonic [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608998.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2MV53, Q8MSM0, Q9VMH0
    Conserved Domains (1) summary
    pfam07773
    Location:117 → 403
    DUF1619; Protein of unknown function (DUF1619)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMH0.4 Q9VMH0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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