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RfC3 Replication factor C subunit 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34423, updated on 4-Jan-2025

Summary

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Official Symbol
RfC3provided by FlyBase
Official Full Name
Replication factor C subunit 3provided by FlyBase
Primary source
FLYBASE:FBgn0032244
Locus tag
Dmel_CG5313
See related
AllianceGenome:FB:FBgn0032244
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5313; Dmel\CG5313; DmRFC3; DRFC; rfc3; Rfc3
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair; leading strand elongation; and sister chromatid cohesion. Part of Elg1 RFC-like complex. Is expressed in organism. Orthologous to human RFC5 (replication factor C subunit 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See RfC3 in Genome Data Viewer
Location:
31E1-31E1; 2-42 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10419190..10420612)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10419190..10420612)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 31E Neighboring gene pineapple eye Neighboring gene WD repeat and FYVE domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. Krause SA, et al. Mol Cell Biol, 2001 Aug. PMID 11438670, Free PMC Article
  2. Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway. Tsuchiya A, et al. FEBS J, 2007 Apr. PMID 17381512
  3. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
  4. The function of replication and SCF complex during Drosophila wing development. Kohzaki H. Front Biosci (Landmark Ed), 2018 Jun 1. PMID 29772558
  5. HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster. De Lucia F, et al. Nucleic Acids Res, 2005. PMID 15905474, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leading strand elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Elg1 RFC-like complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
replication factor C subunit 3
Names
CG5313-PA
RfC3-PA
drosophila replication factor C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10419190..10420612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135555.3 → NP_609399.1  replication factor C subunit 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NGN8, Q9VKW3
    Related
    FBpp0079609
    Conserved Domains (1) summary
    PRK00440
    Location:12 → 321
    rfc; replication factor C small subunit; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKW3 Q9VKW3

Gene LinkOut

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