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CG6614 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34583, updated on 4-Jan-2025

Summary

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Official Symbol
CG6614provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032369
Locus tag
Dmel_CG6614
See related
AllianceGenome:FB:FBgn0032369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6614
Summary
Predicted to be involved in cilium assembly and cilium movement. Predicted to be active in motile cilium. Human ortholog(s) of this gene implicated in spermatogenic failure 41. Orthologous to human CFAP70 (cilia and flagella associated protein 70). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6614 in Genome Data Viewer
Location:
32F4-32F4; 2-44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11644619..11648839, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11644619..11648839, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kekkon 2 Neighboring gene Accessory gland-specific peptide 33A Neighboring gene sperm-associated antigen 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
  2. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848
  3. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article
  4. Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster. Liu X, et al. RNA, 2017 Dec. PMID 28851752, Free PMC Article
  5. The Release 6 reference sequence of the Drosophila melanogaster genome. Hoskins RA, et al. Genome Res, 2015 Mar. PMID 25589440, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6614-PA
CG6614-PB
CG6614-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11644619..11648839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298916.1 → NP_001285845.1  uncharacterized protein Dmel_CG6614, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRL8, Q9VKG0
    Conserved Domains (2) summary
    sd00006
    Location:913 → 947
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:919 → 982
    TPR_11; TPR repeat

  2. NM_001298915.1 → NP_001285844.1  uncharacterized protein Dmel_CG6614, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J5P7

  3. NM_135667.4 → NP_609511.3  uncharacterized protein Dmel_CG6614, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609511.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRL8, Q9VKG0
    Conserved Domains (2) summary
    sd00006
    Location:913 → 947
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:919 → 982
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKG0 Q9VKG0
X2J5P7 X2J5P7

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