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UK114 UK114 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34897, updated on 4-Jan-2025

Summary

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Official Symbol
UK114provided by FlyBase
Official Full Name
UK114provided by FlyBase
Primary source
FLYBASE:FBgn0086691
Locus tag
Dmel_CG15261
See related
AllianceGenome:FB:FBgn0086691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM01181; BG:DS07851.3; CG15261; Dmel\CG15261; DUK 114; DUK114
Summary
Enables protein folding chaperone. Involved in protein folding. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic proventriculus inner layer; embryonic/larval posterior spiracle; and gut section. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See UK114 in Genome Data Viewer
Location:
35D1-35D1; 2-51 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15274181..15275091, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15274181..15275091, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Uxt prefoldin-like subunit Neighboring gene yuri gagarin Neighboring gene Cullin 3 Neighboring gene long non-coding RNA:CR43682 Neighboring gene long non-coding RNA:CR45349

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone. Farkas A, et al. Biochem J, 2004 Oct 1. PMID 15250825, Free PMC Article
  2. The intriguing Ca2+ requirement of calpain activation. Friedrich P. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451413
  3. The calpain-system of Drosophila melanogaster: coming of age. Friedrich P, et al. Bioessays, 2004 Oct. PMID 15382138
  4. Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster. Nicol A, et al. PLoS One, 2024. PMID 39196987, Free PMC Article
  5. Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge. Alias Z, et al. Proteomics, 2007 Oct. PMID 17907271

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cloning and characterization of DUK114, the Drosophila orthologue of UK114.
    Title: DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UK114
Names
CG15261-PA
CG15261-PB
UK114-PA
UK114-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    15274181..15275091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273536.1 → NP_001260465.1  UK114, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260465.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3W0
    Conserved Domains (1) summary
    cl10015
    Location:6 → 127
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...

  2. NM_135903.3 → NP_609747.1  UK114, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609747.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3W0
    Related
    FBpp0080305
    Conserved Domains (1) summary
    cl10015
    Location:6 → 127
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3W0.1 Q9V3W0

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