U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CadN2 Cadherin-N2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35071, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CadN2provided by FlyBase
Official Full Name
Cadherin-N2provided by FlyBase
Primary source
FLYBASE:FBgn0262018
Locus tag
Dmel_CG42829
See related
AllianceGenome:FB:FBgn0262018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cadN2; CG42829; CG7527; CT23007; Dmel\CG42829; DmNCad2; DN-cad2; DN-Cad2; DN-like; DNcad2; N-Cad2; Ncad2; NCad2
Old locus tag
Dmel_CG7527
Summary
Predicted to enable beta-catenin binding activity; cadherin binding activity; and calcium ion binding activity. Involved in axon extension involved in axon guidance and compound eye morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Is expressed in adult head. Orthologous to human CDH26 (cadherin 26). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CadN2 in Genome Data Viewer
Location:
36D3-36E1; 2-53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17786971..17875247, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17786971..17875247, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45699 Neighboring gene Cadherin-N Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43419 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43420 Neighboring gene long non-coding RNA:CR45332

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents. Yonekura S, et al. Dev Biol, 2007 Apr 15. PMID 17320070, Free PMC Article
  2. Evolution: structural and functional diversity of cadherin at the adherens junction. Oda H, et al. J Cell Biol, 2011 Jun 27. PMID 21708975, Free PMC Article
  3. The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development. Biersmith B, et al. PLoS One, 2011 Jan 25. PMID 21283588, Free PMC Article
  4. Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets. Prakash S, et al. Nat Neurosci, 2005 Apr. PMID 15735641, Free PMC Article
  5. Epigenetic control of learning and memory in Drosophila by Tip60 HAT action. Xu S, et al. Genetics, 2014 Dec. PMID 25326235, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: c17825122-17819978 mobile_element_type = transposon:copia{}399

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in R7 cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in R8 cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ommatidial rotation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Cadherin-N2
Names
CG42829-PC
CG42829-PD
CadN2-PC
CadN2-PD
DN-cadh-like
DN-cadherin
N-cadherin2
cadherin N2r

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17786971..17875247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136011.4 → NP_609855.3  Cadherin-N2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609855.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G4LU36, Q0E8P8, Q9VJB6
    Conserved Domains (6) summary
    cd11304
    Location:489 → 586
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:1497 → 1535
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1013 → 1198
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01049
    Location:1583 → 1719
    Cadherin_C; Cadherin cytoplasmic region
    pfam02210
    Location:1293 → 1428
    Laminin_G_2; Laminin G domain
    pfam07974
    Location:1233 → 1259
    EGF_2; EGF-like domain

  2. NM_001042903.4 → NP_001036368.2  Cadherin-N2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036368.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G4LU36, Q0E8P8, Q9VJB6
    Conserved Domains (6) summary
    cd11304
    Location:489 → 586
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:1497 → 1535
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1013 → 1198
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01049
    Location:1583 → 1719
    Cadherin_C; Cadherin cytoplasmic region
    pfam02210
    Location:1293 → 1428
    Laminin_G_2; Laminin G domain
    pfam07974
    Location:1233 → 1259
    EGF_2; EGF-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJB6.3 Q9VJB6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous