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Hasp Hig-anchoring scaffold protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35238, updated on 9-Dec-2024

Summary

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Official Symbol
Haspprovided by FlyBase
Official Full Name
Hig-anchoring scaffold proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032797
Locus tag
Dmel_CG10186
See related
AllianceGenome:FB:FBgn0032797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey189; CG10186; CT28647; Dmel\CG10186; hasp
Summary
Predicted to enable peptidase inhibitor activity. Predicted to be involved in regulation of dendrite development. Located in synaptic cleft. Is expressed in adult brain; adult head; gnathal ganglion; and mushroom body calyx. Human ortholog(s) of this gene implicated in malaria. Orthologous to human CR1 (complement C3b/C4b receptor 1 (Knops blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Hasp in Genome Data Viewer
Location:
37E5-37E5; 2-54 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19508953..19517204, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19508953..19517204, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Topoisomerase 3alpha Neighboring gene cysts Neighboring gene long non-coding RNA:CR43363 Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis. Nakayama M, et al. J Neurosci, 2016 Jan 13. PMID 26758847, Free PMC Article
  2. Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors in Drosophila Neural Development and Physiology. Rosenthal JS, et al. Front Cell Neurosci, 2021. PMID 34650404, Free PMC Article
  3. Stonewalling Drosophila stem cell differentiation by epigenetic controls. Maines JZ, et al. Development, 2007 Apr. PMID 17344229
  4. Transcriptional Programs of Circuit Assembly in the Drosophila Visual System. Kurmangaliyev YZ, et al. Neuron, 2020 Dec 23. PMID 33125872
  5. Identification of proteasome components required for apical localization of Chaoptin using functional genomics. Yano H, et al. J Neurogenet, 2012 Mar. PMID 22417167

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Hig-anchoring scaffold protein
Names
CG10186-PA
CG10186-PC
CG10186-PD
CG10186-PG
CG10186-PH
Hasp-PA
Hasp-PC
Hasp-PD
Hasp-PG
Hasp-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19508953..19517204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136134.7 → NP_609978.4  Hig-anchoring scaffold protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609978.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FNP2, Q8INW2
    Related
    FBpp0080818
    Conserved Domains (4) summary
    cd00033
    Location:307 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:365 → 420
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:114 → 360
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:515 → 576
    Sushi; Sushi repeat (SCR repeat)

  2. NM_001144370.3 → NP_001137842.2  Hig-anchoring scaffold protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137842.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FNP2, B7YZX0
    Conserved Domains (4) summary
    cd00033
    Location:307 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:365 → 420
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:114 → 360
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:515 → 576
    Sushi; Sushi repeat (SCR repeat)

  3. NM_001169545.2 → NP_001163016.1  Hig-anchoring scaffold protein, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163016.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FNP2, B7YZX0
    Conserved Domains (4) summary
    cd00033
    Location:307 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:365 → 420
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:114 → 360
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:515 → 576
    Sushi; Sushi repeat (SCR repeat)

  4. NM_165306.4 → NP_724204.1  Hig-anchoring scaffold protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FNP2, Q9VIU9
    Related
    FBpp0080819
    Conserved Domains (4) summary
    cd00033
    Location:307 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:365 → 420
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:114 → 360
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:515 → 576
    Sushi; Sushi repeat (SCR repeat)

  5. NM_001144368.2 → NP_001137840.1  Hig-anchoring scaffold protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058W1
    Conserved Domains (1) summary
    PHA02927
    Location:112 → 300
    PHA02927; secreted complement-binding protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7YZX0 B7YZX0
Q058W1 Q058W1
Q8INW2 Q8INW2
Q9VIU9 Q9VIU9

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