Clamp Chromatin-linked adaptor for MSL proteins [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Clampprovided by FlyBase
Official Full Name: Chromatin-linked adaptor for MSL proteinsprovided by FlyBase
Primary source: FLYBASE:FBgn0032979
Locus tag: Dmel_CG1832
See related: AllianceGenome:FB:FBgn0032979
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1832; clamp; CLAMP; Dmel\CG1832
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin-protein adaptor activity. Involved in dosage compensation by hyperactivation of X chromosome; maternal-to-zygotic transition of gene expression; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is active in histone locus body. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 40F2-40F2; 2-54 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (22165720..22169143, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (22165720..22169143, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sequence reliance of the Drosophila context-dependent transcription factor CLAMP.
Title: Sequence reliance of the Drosophila context-dependent transcription factor CLAMP.
Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila.
Title: Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila.
Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites.
Title: Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites.
Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.
Title: Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.
Dimerization Activity of a Disordered N-Terminal Domain from Drosophila CLAMP Protein.
Title: Dimerization Activity of a Disordered N-Terminal Domain from Drosophila CLAMP Protein.
CLAMP regulates zygotic genome activation in Drosophila embryos.
Title: CLAMP regulates zygotic genome activation in Drosophila embryos.
The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome.
Title: The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome.
CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
Title: CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
proper MSL2 positioning requires an interaction with either CLAMP or DNA to initiate dosage compensation in Drosophila males.
Title: The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males.
hese are explained by physical interaction between MSL2 and CLAMP. In vivo, both factors cooperate to compete with nucleosome formation at HAS. The male-specific MSL2 thus synergises with a ubiquitous GA-repeat binding protein for refined X/autosome discrimination
Title: Factor cooperation for chromosome discrimination in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin-protein adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in dosage compensation by hyperactivation of X chromosome	IDA Inferred from Direct Assay more info	PubMed
involved_in maternal-to-zygotic transition of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in histone locus body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Chromatin-linked adaptor for MSL proteins

Names: CG1832-PA; CG1832-PB; Clamp-PA; Clamp-PB; chromatin-linked adaptor for MSL proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

22165720..22169143 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014498.3 → NP_001014498.1 Chromatin-linked adaptor for MSL proteins, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014498.1

Status: REVIEWED

Conserved Domains (3) summary

COG5048
Location:359 → 498

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:423 → 443

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:464 → 488

zf-H2C2_2; Zinc-finger double domain
NM_136293.4 → NP_610137.1 Chromatin-linked adaptor for MSL proteins, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610137.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IGP5, Q961A1, Q9V9N4

Related

FBpp0085317

Conserved Domains (3) summary

COG5048
Location:344 → 493

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:418 → 438

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:459 → 483

zf-H2C2_2; Zinc-finger double domain