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Ir40a Ionotropic receptor 40a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35449, updated on 4-Jan-2025

Summary

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Official Symbol
Ir40aprovided by FlyBase
Official Full Name
Ionotropic receptor 40aprovided by FlyBase
Primary source
FLYBASE:FBgn0259683
Locus tag
Dmel_CG42352
See related
AllianceGenome:FB:FBgn0259683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
40a; CG42352; CG5922; CG5929; DmelIR40a; Dmel\CG42352; Ir40A; IR40a
Old locus tag
Dmel_CG5922; Dmel_CG5929
Summary
Predicted to enable ligand-gated monoatomic ion channel activity. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Is expressed in adult hygrosensory neuron Ir40a; adult thermosensory neurons; antennal lobe glomerulus VP; and antennal segment 3 sense organ. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ir40a in Genome Data Viewer
Location:
40F3-40F4; 2-54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22189526..22214376, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22189526..22214376, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44809 Neighboring gene uncharacterized protein Neighboring gene Microsomal glutathione S-transferase-like pseudogene Neighboring gene long non-coding RNA:CR43765

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ir40a neurons are not DEET detectors. Silbering AF, et al. Nature, 2016 Jun 23. PMID 27337300
  2. Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila. Knecht ZA, et al. Elife, 2017 Jun 16. PMID 28621663, Free PMC Article
  3. Early Integration of Temperature and Humidity Stimuli in the Drosophila Brain. Frank DD, et al. Curr Biol, 2017 Aug 7. PMID 28736172, Free PMC Article
  4. Humidity response depends on the small soluble protein Obp59a in Drosophila. Sun JS, et al. Elife, 2018 Sep 19. PMID 30230472, Free PMC Article
  5. Humidity Sensing in Drosophila. Enjin A, et al. Curr Biol, 2016 May 23. PMID 27161501, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: c22192732-22192652 mobile_element_type = transposon:gypsy8{}2095
  • Loc: c22193315-22192908 mobile_element_type = transposon:INE-1{}6140
  • Loc: c22193889-22193767 mobile_element_type = transposon:diver2{}2070
  • Loc: c22196064-22195667 mobile_element_type = transposon:INE-1{}6141
  • Loc: c22200623-22199990 mobile_element_type = transposon:FB{}538
  • Loc: c22206551-22201408 mobile_element_type = transposon:copia{}539
  • Loc: c22207089-22201105 mobile_element_type = transposon:Cr1a{}1995
  • Loc: c22209490-22200858 mobile_element_type = transposon:Cr1a{}2297
  • Loc: c22209920-22209491 mobile_element_type = transposon:INE-1{}6151

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic ion channel activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of chemical stimulus involved in sensory perception IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
ionotropic receptor 40a
Names
CG42352-PE
CG42352-PF
CG42352-PG
Ir40a-PE
Ir40a-PF
Ir40a-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22189526..22214376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136296.4 → NP_610140.4  ionotropic receptor 40a, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610140.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3DNK0, Q9V9N1
    Conserved Domains (2) summary
    cl21456
    Location:496 → 637
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    cl25412
    Location:216 → 338
    PBP2_LTTR_substrate; The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily

  2. NM_001299203.1 → NP_001286132.1  ionotropic receptor 40a, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286132.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAN0
    Conserved Domains (1) summary
    cl21456
    Location:12 → 128
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  3. NM_001273758.2 → NP_001260687.1  ionotropic receptor 40a, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260687.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGG3
    Conserved Domains (1) summary
    cl21456
    Location:44 → 185
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGG3 M9PGG3
Q9V9N1.4 Q9V9N1
X2JAN0 X2JAN0

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