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Rpp25 Ribonuclease P/MRP subunit p25 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35574, updated on 9-Dec-2024

Summary

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Official Symbol
Rpp25provided by FlyBase
Official Full Name
Ribonuclease P/MRP subunit p25provided by FlyBase
Primary source
FLYBASE:FBgn0033092
Locus tag
Dmel_CG9422
See related
AllianceGenome:FB:FBgn0033092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE35072; CG9422; Dmel\CG9422; Pop6
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of multimeric ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP25 (ribonuclease P and MRP subunit p25) and RPP25L (ribonuclease P/MRP subunit p25 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Rpp25 in Genome Data Viewer
Location:
42C4-42C5; 2-55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6675822..6693162)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2563327..2580667)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate C5-epimerase Neighboring gene Post-GPI attachment to proteins 3 Neighboring gene uncharacterized protein Neighboring gene Tyrosine decarboxylase 1 Neighboring gene long non-coding RNA:CR44164 Neighboring gene antisense RNA:CR44165 Neighboring gene uncharacterized protein Neighboring gene Tyrosine decarboxylase 2 Neighboring gene uncharacterized protein Neighboring gene MOB kinase activator 4 Neighboring gene Rab2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biogenesis of RNase P RNA from an intron requires co-assembly with cognate protein subunits. Palsule G, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287870, Free PMC Article
  2. Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signaling. Rendina R, et al. Genetics, 2010 Sep. PMID 20551433, Free PMC Article
  3. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Rosenblad MA, et al. Nucleic Acids Res, 2006. PMID 16998185, Free PMC Article
  4. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
  5. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Glatter T, et al. Mol Syst Biol, 2011 Nov 8. PMID 22068330, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonuclease P RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribonuclease P/MRP subunit p25
Names
CG9422-PA
CG9422-PC
CG9422-PD
Rpp25-PA
Rpp25-PC
Rpp25-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6675822..6693162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136383.4 → NP_610227.2  ribonuclease P/MRP subunit p25, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610227.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9N4, Q6NNC7
    Related
    FBpp0085455
    Conserved Domains (1) summary
    pfam01918
    Location:34 → 97
    Alba; Alba

  2. NM_165484.3 → NP_724490.1  ribonuclease P/MRP subunit p25, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724490.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9N4, Q6NNC7
    Related
    FBpp0085454
    Conserved Domains (1) summary
    pfam01918
    Location:34 → 97
    Alba; Alba

  3. NM_001259221.2 → NP_001246150.1  ribonuclease P/MRP subunit p25, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246150.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9N4, Q6NNC7
    Conserved Domains (1) summary
    pfam01918
    Location:34 → 97
    Alba; Alba
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E9N4 Q0E9N4
Q8SXI3 Q8SXI3

Gene LinkOut

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