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Tsp42Ej Tetraspanin 42Ej [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35620, updated on 4-Jan-2025

Summary

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Official Symbol
Tsp42Ejprovided by FlyBase
Official Full Name
Tetraspanin 42Ejprovided by FlyBase
Primary source
FLYBASE:FBgn0033132
Locus tag
Dmel_CG12143
See related
AllianceGenome:FB:FBgn0033132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12143; Dm.Tsp42Ej; Dmel\CG12143; sun; Sun; tsp42ej
Summary
Involved in cellular response to high light intensity and endocytosis. Located in lysosome. Is expressed in several structures, including adult head; embryonic esophagus; embryonic head epidermis; embryonic/larval garland cell; and ganglia. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 5. Orthologous to several human genes including TSPAN1 (tetraspanin 1); TSPAN12 (tetraspanin 12); and TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Tsp42Ej in Genome Data Viewer
Location:
42E5-42E5; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7040136..7042762)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2927641..2930267)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Ei Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Tetraspanin 42Ek Neighboring gene Tetraspanin 42El Neighboring gene late bloomer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overlapping but Distinct Sequences Play Roles in the Insulator and Promoter Activities of the Drosophila BEAF-Dependent scs' Insulator. Maharjan M, et al. Genetics, 2020 Aug. PMID 32554599, Free PMC Article
  2. Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. Venkatachalam K, et al. J Biol Chem, 2006 Jun 23. PMID 16606612, Free PMC Article
  3. Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity. Han J, et al. EMBO J, 2007 Dec 12. PMID 18034157, Free PMC Article
  4. Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Lee SJ, et al. Curr Biol, 2004 Dec 14. PMID 15589149
  5. Use of a Drosophila model to identify genes regulating Plasmodium growth in the mosquito. Brandt SM, et al. Genetics, 2008 Nov. PMID 18791251, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sun protein was distributed primarily in lysosomes, and functioned in light-induced degradation of rhodopsin.
    Title: A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to high light intensity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin 42Ej
Names
CG12143-PA
Tsp42Ej-PA
sunglass
sunglasses
tetraspanin 42E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7040136..7042762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078912.3 → NP_523636.1  tetraspanin 42Ej [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523636.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3Z2
    Related
    FBpp0088101
    Conserved Domains (2) summary
    cd03127
    Location:97 → 183
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:11 → 211
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3Z2 Q7K3Z2

Gene LinkOut

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