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LRP1 LDL receptor protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35799, updated on 4-Jan-2025

Summary

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Official Symbol
LRP1provided by FlyBase
Official Full Name
LDL receptor protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0053087
Locus tag
Dmel_CG33087
See related
AllianceGenome:FB:FBgn0053087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30368; CG33087; CG8706; CT9297; Dm CG33087; Dmel\CG33087; dmLRP1; LRP-1; lrp1; Lrp1
Summary
Predicted to enable low-density lipoprotein particle receptor activity. Involved in regulation of axon guidance. Located in dendrite. Is expressed in adult brain cell body rind; adult head; and spermatozoon. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); keratosis pilaris atrophicans; lung disease (multiple); myocardial infarction; and sciatic neuropathy. Orthologous to several human genes including LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See LRP1 in Genome Data Viewer
Location:
44B8-44C2; 2-58 cM
Exon count:
23
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8174165..8226438)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4061670..4113943)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene gasz Neighboring gene uncharacterized protein Neighboring gene Mlh1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44275 Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA 4 Neighboring gene deadpan

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport. Zhang JM, et al. J Mol Neurosci, 2022 Aug. PMID 35668313
  2. Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier. Li F, et al. Elife, 2023 May 4. PMID 37140181, Free PMC Article
  3. Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis. Vialat M, et al. Cancers (Basel), 2024 Jun 6. PMID 38893271, Free PMC Article
  4. A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila. Singh A, et al. Nat Commun, 2024 May 23. PMID 38782979, Free PMC Article
  5. Genomic and Transcriptomic Associations Identify a New Insecticide Resistance Phenotype for the Selective Sweep at the Cyp6g1 Locus of Drosophila melanogaster. Battlay P, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317781, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of lipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LDL receptor protein 1
Names
CG33087-PF
CG33087-PG
LDL receptor protein
LDL receptor-related protein 1
LDL-receptor-related protein 1
LRP1-PF
LRP1-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8174165..8226438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273871.2 → NP_001260800.2  LDL receptor protein 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260800.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFD1
    Conserved Domains (9) summary
    smart00192
    Location:3776 → 3808
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2475 → 2517
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:3103 → 3141
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4415 → 4450
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:2810 → 2844
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:2082 → 2120
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:449 → 487
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:1289 → 1317
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:2082 → 2152
    NHL; NHL repeat unit of beta-propeller proteins

  2. NM_176104.3 → NP_788284.3  LDL receptor protein 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788284.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7C4
    Conserved Domains (9) summary
    smart00192
    Location:3750 → 3782
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2449 → 2491
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:3077 → 3115
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4389 → 4424
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:2784 → 2818
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:2056 → 2094
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:423 → 461
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:1263 → 1291
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:2056 → 2126
    NHL; NHL repeat unit of beta-propeller proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFD1 A0A0B4KFD1
A1Z7C4 A1Z7C4

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