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Rme-8 Receptor mediated endocytosis 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35939, updated on 4-Jan-2025

Summary

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Official Symbol
Rme-8provided by FlyBase
Official Full Name
Receptor mediated endocytosis 8provided by FlyBase
Primary source
FLYBASE:FBgn0015477
Locus tag
Dmel_CG8014
See related
AllianceGenome:FB:FBgn0015477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8014; Dmel\CG8014; E(shi)2-1; l(2)45Ba; rme-8
Summary
Involved in positive regulation of border follicle cell migration and receptor-mediated endocytosis. Predicted to be active in endosome membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic Malpighian tubule; embryonic/larval garland cell; and spermatozoon. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Rme-8 in Genome Data Viewer
Location:
45B1-45B2; 2-60 cM
Exon count:
22
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9167763..9177261, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5055268..5064766, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rad51 recombinase D Neighboring gene uncharacterized protein Neighboring gene Rab32 Neighboring gene long non-coding RNA:CR44284 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. Gomez-Lamarca MJ, et al. J Cell Biol, 2015 Jul 20. PMID 26169355, Free PMC Article
  2. The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila. Chang HC, et al. J Cell Biol, 2004 Mar 29. PMID 15051737, Free PMC Article
  3. A genetic screen in Drosophila uncovers a role for senseless-2 in surface glia in the peripheral nervous system to regulate CNS morphology. Lacin H, et al. G3 (Bethesda), 2024 Sep 4. PMID 38996053, Free PMC Article
  4. [Cytogenetic analysis of the chromosome region containing the Drosophila radiosensitivity gene. II. The vitally important loci of the 44F-45C region of chromosome 2]. Konev AIu, et al. Genetika, 1994 Feb. PMID 8045382
  5. The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila. Rosa-Ferreira C, et al. Biol Open, 2018 Sep 5. PMID 30115618, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rme-8 is necessary for normal Notch recycling.
    Title: Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling.
  2. Endosomal organization and the distribution of clathrin were greatly disrupted in Rme-8 cells, suggesting that Rme-8 participates in a clathrin-dependent process.
    Title: The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
receptor mediated endocytosis 8
Names
CG8014-PA
CG8014-PB
Rme-8-PA
Rme-8-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9167763..9177261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299307.1 → NP_001286236.1  receptor mediated endocytosis 8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286236.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFW6
    Conserved Domains (3) summary
    pfam00226
    Location:1303 → 1355
    DnaJ; DnaJ domain
    pfam14237
    Location:971 → 1019
    DUF4339; Domain of unknown function (DUF4339)
    sd00044
    Location:2173 → 2199
    HEAT; HEAT repeat [structural motif]

  2. NM_136623.2 → NP_610467.1  receptor mediated endocytosis 8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610467.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7S0
    Related
    FBpp0087699
    Conserved Domains (3) summary
    pfam00226
    Location:1304 → 1356
    DnaJ; DnaJ domain
    pfam14237
    Location:972 → 1020
    DUF4339; Domain of unknown function (DUF4339)
    sd00044
    Location:2174 → 2200
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFW6 A0A0B4LFW6
A1Z7S0 A1Z7S0

Gene LinkOut

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