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Sobp Sine oculis-binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36260, updated on 9-Dec-2024

Summary

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Official Symbol
Sobpprovided by FlyBase
Official Full Name
Sine oculis-binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033654
Locus tag
Dmel_CG8991
See related
AllianceGenome:FB:FBgn0033654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8991; Dmel\CG8991; Sbp; SOBP
Summary
Enables DNA-binding transcription factor binding activity. Involved in compound eye development. Predicted to be active in nucleus. Is expressed in border follicle cell; dorsal pharyngeal muscle cell; larval muscle system; larval somatic muscle cell; and larval visceral muscle cell. Orthologous to human SOBP (sine oculis binding protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Sobp in Genome Data Viewer
Location:
48C4-48C4; 2-65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11827170..11839825, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7714675..7727330, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene thisbe Neighboring gene Ionotropic receptor 48c Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44304 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene site-2 protease

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myogenesis control by SIX transcriptional complexes. Maire P, et al. Semin Cell Dev Biol, 2020 Aug. PMID 32247726
  2. Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development. Kenyon KL, et al. Dev Biol, 2005 Oct 1. PMID 16125693
  3. Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. Kenyon KL, et al. Dev Dyn, 2005 Nov. PMID 15937930
  4. Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network. Davis TL, et al. Fly (Austin), 2018 Jan 2. PMID 29125381, Free PMC Article
  5. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sine oculis-binding protein
Names
CG8991-PA
CG8991-PB
Sobp-PA
Sobp-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11827170..11839825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136859.3 → NP_610703.3  sine oculis-binding protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610703.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5X798, Q95TY2, Q9V620
    Related
    FBpp0087170
    Conserved Domains (2) summary
    pfam15279
    Location:278 → 587
    SOBP; Sine oculis-binding protein
    cl00909
    Location:275 → 312
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...

  2. NM_001299391.1 → NP_001286320.1  sine oculis-binding protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5X798, Q95TY2, Q9V620
    Conserved Domains (2) summary
    pfam15279
    Location:278 → 587
    SOBP; Sine oculis-binding protein
    cl00909
    Location:275 → 312
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TY2 Q95TY2

Gene LinkOut

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