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Drep1 DNA fragmentation factor-related protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36290, updated on 4-Jan-2025

Summary

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Official Symbol
Drep1provided by FlyBase
Official Full Name
DNA fragmentation factor-related protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0024732
Locus tag
Dmel_CG8357
See related
AllianceGenome:FB:FBgn0024732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8357; dICAD; Dmel\CG8357; Drep-1; DREP-1; DREP-1/dICAD; drep1; DREP1; ICAD; ICAD/DREP-1; Rep1
Summary
Enables protein sequestering activity. Involved in negative regulation of apoptotic process and nurse cell apoptotic process. Is expressed in organism. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5 and obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a); CIDEB (cell death inducing DFFA like effector b); and CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Drep1 in Genome Data Viewer
Location:
48D8-48D8; 2-65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12044612..12050172)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7932117..7937677)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene upstream of RpIII128 Neighboring gene RNA polymerase III subunit B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA fragmentation factor-related protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A putative role of Drep1 in apoptotic DNA fragmentation system in fly is mediated by direct interaction with Drep2 and Drep4. Park OK, et al. Apoptosis, 2013 Apr. PMID 23417746
  2. Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogaster. Mukae N, et al. J Biol Chem, 2000 Jul 14. PMID 10781612
  3. In vitro analysis of the complete CIDE domain interactions of the Drep system in fly. Lee SM, et al. Apoptosis, 2014 Mar. PMID 24233238
  4. General interaction mode of CIDE:CIDE complex revealed by a mutation study of the Drep2 CIDE domain. Lee SM, et al. FEBS Lett, 2013 Apr 2. PMID 23485826
  5. A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster. Yokoyama H, et al. J Biol Chem, 2000 Apr 28. PMID 10777599

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study suggests that Drep1 might be involved in apoptotic DNA fragmentation of fly system by direct interaction with Drep2 as well as Drep4
    Title: A putative role of Drep1 in apoptotic DNA fragmentation system in fly is mediated by direct interaction with Drep2 and Drep4.
  2. Data indicate that the basic surface side of Drep2 CIDE is involved in the interaction with the acidic surface side of Drep1 CIDE and Drep3 CIDE.
    Title: General interaction mode of CIDE:CIDE complex revealed by a mutation study of the Drep2 CIDE domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables deoxyribonuclease inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein sequestering activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nurse cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
DNA fragmentation factor-related protein 1
Names
CG8357-PA
CG8357-PB
DFF45-related protein-1
Drep1-PA
Drep1-PB
Rep1
inhibitor of CAD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12044612..12050172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136877.5 → NP_610721.2  DNA fragmentation factor-related protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610721.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61464, Q6NR36
    Related
    FBpp0087086
    Conserved Domains (1) summary
    smart00266
    Location:12 → 85
    CAD; Domains present in proteins implicated in post-mortem DNA fragmentation

  2. NM_001273980.2 → NP_001260909.1  DNA fragmentation factor-related protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260909.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFQ3, O61464
    Conserved Domains (1) summary
    smart00266
    Location:12 → 85
    CAD; Domains present in proteins implicated in post-mortem DNA fragmentation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFQ3 A0A0B4KFQ3
O61464 O61464
Q6NR36 Q6NR36

Gene LinkOut

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