CG6191 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG6191provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0027581
Locus tag: Dmel_CG6191
See related: AllianceGenome:FB:FBgn0027581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH06193; Dmel\CG6191; Dromel_CG6191_FBtr0087678_mORF
Summary: Involved in motile cilium assembly and non-motile cilium assembly. Located in ciliary basal body. Is expressed in several structures, including adult head; compartment boundary; female germline stem cell; larval brain; and larval central nervous system. Orthologous to human CABLES1 (Cdk5 and Abl enzyme substrate 1) and CABLES2 (Cdk5 and Abl enzyme substrate 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 50B3-50B4; 2-68 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13580313..13593339, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9467818..9480844, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c13580842-13580578 mobile_element_type = transposon:jockey{}820

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uncharacterized protein

Names: CG6191-PA; CG6191-PB; CG6191-PC; cables

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13580313..13593339 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274028.2 → NP_001260957.1 uncharacterized protein Dmel_CG6191, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260957.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEN8, Q9Y138

Conserved Domains (1) summary

cl00050
Location:590 → 710

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_137046.5 → NP_610890.2 uncharacterized protein Dmel_CG6191, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610890.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9G1, Q9Y138

Related

FBpp0086798

Conserved Domains (1) summary

cl00050
Location:579 → 699

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_001274029.2 → NP_001260958.1 uncharacterized protein Dmel_CG6191, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260958.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF19, Q9Y138

Conserved Domains (1) summary

cl00050
Location:579 → 699

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...