gad1b glutamate decarboxylase 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gad1bprovided by ZNC
Official Full Name: glutamate decarboxylase 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030909-3
See related: Ensembl:ENSDARG00000027419 AllianceGenome:ZFIN:ZDB-GENE-030909-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gad1; GAD67
Summary: Predicted to enable glutamate decarboxylase activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process. Predicted to be active in cytoplasm and presynaptic active zone. Is expressed in nervous system and neural tube. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; drug psychosis; and heroin dependence. Orthologous to human GAD1 (glutamate decarboxylase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (3827750..3862113)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (3666870..3701293)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

relative expression domains of the dlx and gad1 genes in the zebrafish telencephalon and diencephalon
Title: The relationship between dlx and gad1 expression indicates highly conserved genetic pathways in the zebrafish forebrain.
the distribution of GAD67-expressing cells highly resembles the distribution of gamma-aminobutyric acid (GABA)/GAD67-expressing cells found in the early zebrafish (teleost) forebrain, suggesting a prosomeric fate map of GABAergic cell populations
Title: The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods.
High levels of GAD67 mRNA were observed in the intermediate and ventral parts of the medial pallium
Title: Molecular characterization and comparative localization of the mRNAs encoding two glutamic acid decarboxylases (GAD65 and GAD67) in the brain of the African lungfish, Protopterus annectens.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables glutamate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamate decarboxylase 1b

Names: glutamate decarboxylase 1

NP_919400.1

EC 4.1.1.15

XP_009300378.1

EC 4.1.1.15

XP_009300379.1

EC 4.1.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.