U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PIG-Wb Phosphatidylinositol glycan anchor biosynthesis class W b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38220, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
PIG-Wbprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class W bprovided by FlyBase
Primary source
FLYBASE:FBgn0035265
Locus tag
Dmel_CG18173
See related
AllianceGenome:FB:FBgn0035265
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18173; Dmel\CG18173; PIG-W; PIGWb
Summary
Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PIG-Wb in Genome Data Viewer
Location:
62B1-62B1; 3-1.0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1735853..1738106, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1735853..1738106, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene draper Neighboring gene uncharacterized protein Neighboring gene Outer segment 4 Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized protein Neighboring gene Chitinase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. Akimana C, et al. PLoS One, 2010 Jun 11. PMID 20552012, Free PMC Article
  2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
  4. The genetics of egg retention and fertilization success in Drosophila: One step closer to understanding the transition from facultative to obligate viviparity. Horváth B, et al. Evolution, 2018 Feb. PMID 29265369
  5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol glycan anchor biosynthesis class W b
Names
CG18173-PA
CG18173-PB
PIG-Wb-PA
PIG-Wb-PB
NP_001261279.1
NP_647654.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1735853..1738106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274350.1 → NP_001261279.1  phosphatidylinositol glycan anchor biosynthesis class W b, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261279.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W096
    Conserved Domains (1) summary
    cl02109
    Location:85 → 503
    GWT1; GWT1

  2. NM_139397.3 → NP_647654.1  phosphatidylinositol glycan anchor biosynthesis class W b, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647654.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W096
    Related
    FBpp0072678
    Conserved Domains (1) summary
    cl02109
    Location:85 → 503
    GWT1; GWT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W096 Q9W096

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous