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Mrtf Myocardin-related transcription factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38338, updated on 9-Dec-2024

Summary

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Official Symbol
Mrtfprovided by FlyBase
Official Full Name
Myocardin-related transcription factorprovided by FlyBase
Primary source
FLYBASE:FBgn0052296
Locus tag
Dmel_CG32296
See related
AllianceGenome:FB:FBgn0052296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12188; CG14951; CG32296; Dmel\CG32296; dMrtf; dMRTF; DMRTF; mal; mal-d; Mal-D; MAL-D; MRTF
Summary
Enables DNA-binding transcription factor binding activity and transcription coactivator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including border follicle cell migration; cellular response to hypoxia; and mesodermal cell migration. Located in cytoplasm and nucleus. Is expressed in several structures, including border follicle cell; egg chamber; larval muscle cell; and ovary. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia; congenital megabladder; dilated cardiomyopathy; and immunodeficiency 66. Orthologous to human MYOCD (myocardin); MRTFA (myocardin related transcription factor A); and MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Mrtf in Genome Data Viewer
Location:
62F2-62F3; 3-4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2717615..2766536, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2717615..2766480, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fife Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 62F Neighboring gene Adenosylhomocysteinase like 1 Neighboring gene Novel nucleolar protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features. Andrews JC, et al. Genet Med, 2023 Jun. PMID 37013900, Free PMC Article
  2. The core and conserved role of MAL is homeostatic regulation of actin levels. Salvany L, et al. Genes Dev, 2014 May 15. PMID 24831700, Free PMC Article
  3. The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Pipes GC, et al. Genes Dev, 2006 Jun 15. PMID 16778073
  4. Mal/SRF is dispensable for cell proliferation in Drosophila. Thompson BJ. PLoS One, 2010 Apr 9. PMID 20404916, Free PMC Article
  5. Novel ability of diflubenzuron as an inhibitor of mitochondrial function. Mori K, et al. Insect Biochem Mol Biol, 2024 Apr. PMID 38342197

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in both Drosophila and human cellular models that actin is the key target that must be regulated by MAL/SRF for invasive cell migration
    Title: The core and conserved role of MAL is homeostatic regulation of actin levels.
  2. Border cell migration requires the activity of MAL-D and nuclear accumulation of MAL-D is induced by cell stretching.
    Title: Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration.
  3. Data describe a myocardin-related transcription factor from Drosophila, DMRTF, which is shares homology with mammalian myocardin and MRTFs and stimulates the activity of Drosophila serum response factor
    Title: A myocardin-related transcription factor regulates activity of serum response factor in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Myocardin-related transcription factor
Names
CG32296-PD
CG32296-PG
CG32296-PH
Mrtf-PD
Mrtf-PG
Mrtf-PH
myocardin-related transcription factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2717615..2766536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259651.3 → NP_001246580.1  Myocardin-related transcription factor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6B4I4, Q9VZY2
    Conserved Domains (2) summary
    smart00707
    Location:94 → 119
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:578 → 612
    SAP; SAP domain

  2. NM_001144407.4 → NP_001137879.3  Myocardin-related transcription factor, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137879.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z043, Q6B4I4
    Conserved Domains (2) summary
    smart00707
    Location:387 → 412
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:871 → 905
    SAP; SAP domain

  3. NM_001144406.3 → NP_001137878.2  Myocardin-related transcription factor, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137878.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6B4I4, Q9VZY2
    Conserved Domains (2) summary
    smart00707
    Location:94 → 119
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:578 → 612
    SAP; SAP domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z043 B7Z043
Q6B4I4 Q6B4I4
Q8MZ79 Q8MZ79
Q9VZY2 Q9VZY2

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