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slow slowdown [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38540, updated on 9-Dec-2024

Summary

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Official Symbol
slowprovided by FlyBase
Official Full Name
slowdownprovided by FlyBase
Primary source
FLYBASE:FBgn0035539
Locus tag
Dmel_CG7447
See related
AllianceGenome:FB:FBgn0035539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
blr; CG7447; CT22877; Dmel\CG7447; slomo; Slow
Summary
Predicted to enable signaling receptor binding activity. Involved in muscle attachment and synaptic target recognition. Located in muscle tendon junction. Is expressed in several structures, including Bolwig organ; dorsal ridge; epidermis; muscle cell; and sensory nervous system primordium. Orthologous to several human genes including EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See slow in Genome Data Viewer
Location:
64B3-64B4; 3-12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4384442..4403181)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4384442..4403181)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dopamine/Ecdysteroid receptor Neighboring gene long non-coding RNA:CR44360 Neighboring gene uncharacterized protein Neighboring gene Syntaxin 17 Neighboring gene uncharacterized protein Neighboring gene Tumor protein p53 inducible nuclear protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction. Gilsohn E, et al. Development, 2010 Mar. PMID 20110313
  2. Using qualitative probability in reverse-engineering gene regulatory networks. Ibrahim ZM, et al. IEEE/ACM Trans Comput Biol Bioinform, 2011 Mar-Apr. PMID 20876933
  3. A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7. Zahoor MK, et al. Mol Genet Genomics, 2019 Jun. PMID 30656413
  4. Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes. Kurucz E, et al. Curr Biol, 2007 Apr 3. PMID 17363253
  5. Mechanical Control of Myotendinous Junction Formation and Tendon Differentiation during Development. Valdivia M, et al. Front Cell Dev Biol, 2017. PMID 28386542, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction
    Title: Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in muscle tendon junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
slowdown
Names
CG7447-PA
CG7447-PB
N-like
blade runner
slow-PA
slow-PB
slowdowm
slowmotion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4384442..4403181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139641.3 → NP_647898.3  slowdown, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647898.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RQ1, Q9VZD0
    Related
    FBpp0073147
    Conserved Domains (3) summary
    smart00179
    Location:362 → 401
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:336 → 360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:246 → 318
    EMI; EMI domain

  2. NM_176283.2 → NP_788461.1  slowdown, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788461.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RQ1, Q9VZD0
    Related
    FBpp0073148
    Conserved Domains (3) summary
    smart00179
    Location:362 → 401
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:336 → 360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:246 → 318
    EMI; EMI domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RQ1 Q95RQ1

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