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Tsen54 tRNA splicing endonuclease subunit 54 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39397, updated on 4-Jan-2025

Summary

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Official Symbol
Tsen54provided by FlyBase
Official Full Name
tRNA splicing endonuclease subunit 54provided by FlyBase
Primary source
FLYBASE:FBgn0036266
Locus tag
Dmel_CG5626
See related
AllianceGenome:FB:FBgn0036266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5626; Dmel\CG5626; TSEN54
Summary
Involved in tRNA processing. Predicted to be part of tRNA-intron endonuclease complex. Used to study pontocerebellar hypoplasia type 4. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Tsen54 in Genome Data Viewer
Location:
69A2-69A2; 3-38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12204123..12206022, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12197223..12199122, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Adenylate kinase 1 Neighboring gene approximated Neighboring gene long non-coding RNA:CR43991 Neighboring gene uncharacterized protein Neighboring gene Porphobilinogen synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved motif controls nuclear localization of Drosophila Muscleblind. Fernandez-Costa JM, et al. Mol Cells, 2010 Jul. PMID 20652497
  2. Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia. Schmidt CA, et al. Biol Open, 2022 Mar 15. PMID 35132432, Free PMC Article
  3. RNA kinase CLP1/Cbc regulates meiosis initiation in spermatogenesis. Wu J, et al. Hum Mol Genet, 2021 Aug 12. PMID 33864361, Free PMC Article
  4. Molecular determinants of metazoan tricRNA biogenesis. Schmidt CA, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31032518, Free PMC Article
  5. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA-type intron splice site recognition and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of tRNA-intron endonuclease complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA splicing endonuclease subunit 54
Names
CG5626-PA
Tsen54-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12204123..12206022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140302.2 → NP_648559.1  tRNA splicing endonuclease subunit 54 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648559.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I1WYI0, Q9VTV4
    Related
    FBpp0075748
    Conserved Domains (1) summary
    pfam12928
    Location:66 → 129
    tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTV4 Q9VTV4

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