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Tom Twin of m4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39619, updated on 4-Jan-2025

Summary

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Official Symbol
Tomprovided by FlyBase
Official Full Name
Twin of m4provided by FlyBase
Primary source
FLYBASE:FBgn0026320
Locus tag
Dmel_CG5185
See related
AllianceGenome:FB:FBgn0026320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe1F6; barbu; Bbu; bbu/tom; CG5185; DmelCG5185; Dmel\CG5185; tom
Summary
Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ precursor cell fate determination. Located in cytoplasm. Is expressed in several structures, including ectoderm anlage; epithelium; germ layer; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Tom in Genome Data Viewer
Location:
71A3-71A3; 3-42 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14969344..14970306)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14962444..14963406)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Brother of Bearded A Neighboring gene long non-coding RNA:CR45978 Neighboring gene Bearded Neighboring gene ocho

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional characterization of the NHR1 domain of the Drosophila neuralized E3 ligase in the notch signaling pathway. He F, et al. J Mol Biol, 2009 Oct 23. PMID 19683535
  2. Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development. Nystrom SL, et al. Development, 2020 Mar 16. PMID 32094114, Free PMC Article
  3. Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe. Contreras EG, et al. Neural Dev, 2018 Nov 22. PMID 30466475, Free PMC Article
  4. Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized. Miller SW, et al. PLoS Genet, 2018 Jul. PMID 30028887, Free PMC Article
  5. Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila. Perez-Mockus G, et al. Nat Commun, 2017 Nov 17. PMID 29150614, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snail represses Tom expression in the mesoderm and thereby activates Delta trafficking.
    Title: Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory organ precursor cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
twin of m4
Names
CG5185-PA
Tom-PA
anon-fast-evolving-1F6
barbu

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14969344..14970306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079349.3 → NP_524073.2  twin of m4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524073.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4W9, Q9V3S6
    Related
    FBpp0075373
    Conserved Domains (1) summary
    pfam15952
    Location:1 → 158
    ESM4; Enhancer of split M4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U4W9 Q9U4W9
Q9V3S6 Q9V3S6

Gene LinkOut

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