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MsrA Methionine sulfoxide reductase A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39675, updated on 4-Jan-2025

Summary

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Official Symbol
MsrAprovided by FlyBase
Official Full Name
Methionine sulfoxide reductase Aprovided by FlyBase
Primary source
FLYBASE:FBgn0000565
Locus tag
Dmel_CG7266
See related
AllianceGenome:FB:FBgn0000565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7266; Dmel\CG7266; dmsrA; dMsrA; DROZ60MEX; Eip28; Eip28 /29; eip28/29; Eip28/29; Eip71C; Eip71CD; EiP71CD; msrA; MSRA
Summary
Enables peptide-methionine (S)-S-oxide reductase activity. Involved in cellular response to oxidative stress and determination of adult lifespan. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval hemocyte; epithelium; fat body; and gut section. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See MsrA in Genome Data Viewer
Location:
71D3-71D4; 3-43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15511052..15513202)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15504152..15506302)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene gdl-ORF39 Neighboring gene Z600 Neighboring gene gonadal Neighboring gene uncharacterized protein Neighboring gene midgut expression 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA clones for the ecdysone-inducible polypeptide (EIP) mRNAs of Drosophila Kc cells. Savakis C, et al. EMBO J, 1984 Jan. PMID 16453496, Free PMC Article
  2. Transcriptional response elements in the promoter of CYP6B1, an insect P450 gene regulated by plant chemicals. Petersen RA, et al. Biochim Biophys Acta, 2003 Feb 17. PMID 12573487
  3. Structure of the Eip28/29 gene, an ecdysone-inducible gene from Drosophila. Cherbas L, et al. J Mol Biol, 1986 Jun 20. PMID 3097323
  4. Alternative splicing generates two distinct Eip28/29 gene transcripts in Drosophila Kc cells. Schulz RA, et al. Proc Natl Acad Sci U S A, 1986 Dec. PMID 3099283, Free PMC Article
  5. Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism. Guan XL, et al. Aging Cell, 2017 Apr. PMID 27790859, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan
    Title: The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO.
  2. MsrA and MsrB, the two proteins with similar function in antioxidant protein repair, have different effects on aging in fruit flies.
    Title: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
  3. Hormonal regulation of MsrA is implicated in conferring protection against oxidative stress in the Drosophila model.
    Title: Ecdysone induction of MsrA protects against oxidative stress in Drosophila.
  4. Reaction mechanism, evolutionary analysis, and role of zinc for methionine sulfoxide reductase
    Title: Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-methionine-(S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (S)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (S)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-methionine (S)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur amino acid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
methionine sulfoxide reductase A
Names
CG7266-PA
CG7266-PB
CG7266-PC
CG7266-PE
CG7266-PF
CG7266-PG
Ecdysone-induced protein 28/29kD
Eip28/29
Methionine-S-sulfoxide reductase
MsrA-PA
MsrA-PB
MsrA-PC
MsrA-PE
MsrA-PF
MsrA-PG
methionine reductase A
NP_001261878.1
NP_001261879.1
NP_524085.2
NP_730047.1
NP_730048.1
NP_996093.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15511052..15513202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168623.2 → NP_730048.1  methionine sulfoxide reductase A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730048.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KUN2
    Related
    FBpp0075307
    Conserved Domains (1) summary
    cl00366
    Location:42 → 80
    PMSR; Peptide methionine sulfoxide reductase

  2. NM_079361.3 → NP_524085.2  methionine sulfoxide reductase A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524085.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08761, Q86NL3, Q8IQM6, Q8IT52, Q9VUP3, Q9VUP4, Q9VUP5
    UniProtKB/TrEMBL
    B5X0L2, Q6NLA4
    Related
    FBpp0075308
    Conserved Domains (1) summary
    pfam01625
    Location:42 → 174
    PMSR; Peptide methionine sulfoxide reductase

  3. NM_001274950.1 → NP_001261879.1  methionine sulfoxide reductase A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261879.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCL6, Q6NLA4
    Conserved Domains (1) summary
    pfam01625
    Location:42 → 174
    PMSR; Peptide methionine sulfoxide reductase

  4. NM_168622.2 → NP_730047.1  methionine sulfoxide reductase A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730047.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NLA4
    Related
    FBpp0075309
    Conserved Domains (1) summary
    pfam01625
    Location:42 → 170
    PMSR; Peptide methionine sulfoxide reductase

  5. NM_206371.3 → NP_996093.2  methionine sulfoxide reductase A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996093.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F2FB74, Q7KUM8
    Conserved Domains (1) summary
    pfam01625
    Location:35 → 167
    PMSR; Peptide methionine sulfoxide reductase

  6. NM_001274949.1 → NP_001261878.1  methionine sulfoxide reductase A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261878.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI66, Q6NLA4
    Conserved Domains (1) summary
    pfam01625
    Location:41 → 173
    PMSR; Peptide methionine sulfoxide reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCL6 M9PCL6
M9PI66 M9PI66
P08761.2 P08761
Q6AWF7 Q6AWF7
Q7KUM8 Q7KUM8
Q7KUN2 Q7KUN2

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