Scn4b sodium channel, type IV, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scn4bprovided by MGI
Official Full Name: sodium channel, type IV, betaprovided by MGI
Primary source: MGI:MGI:2687406
See related: Ensembl:ENSMUSG00000046480 AllianceGenome:MGI:2687406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1471
Summary: Enables voltage-gated sodium channel activity. Acts upstream of or within establishment of localization in cell and sodium ion transmembrane transport. Located in intercalated disc. Is expressed in brain; dorsal striatum; and ventral striatum. Human ortholog(s) of this gene implicated in long QT syndrome 10. Orthologous to human SCN4B (sodium voltage-gated channel beta subunit 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in cerebellum adult (RPKM 27.4), cortex adult (RPKM 16.0) and 5 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (45049922..45065453)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (45138624..45154155)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intrinsic mechanisms in the gating of resurgent Na(+) currents.
Title: Intrinsic mechanisms in the gating of resurgent Na(+) currents.
Effects of FGF14 and NaVbeta4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons.
Title: Effects of FGF14 and Na(V)β4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons.
Scn4b was involved in the acute hypnotic effects of ethanol and other sedatives. No evidence that Scn4b regulates ethanol consumption in mice was found.
Title: Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.
Data suggest that extracellular domains of Scn4b directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); Scn4b homodimers appear to play role in cell-cell adhesion.
Title: Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.
Scn4b(-/-) animals have deficits in motor coordination and balance and that firing rates in Scn4b(-/-) Purkinje neurons are markedly attenuated.
Title: Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.
NaVbeta4 plays a blocking role that indicates the relative importance of different residues in inducing open-channel block.
Title: Cross-species conservation of open-channel block by Na channel β4 peptides reveals structural features required for resurgent Na current.
Data show that Na(V)beta4 (Scn4b} expression determines multiple aspects of Na channel gating, thereby regulating excitability in cultured cerebellar granule cells.
Title: Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neurons.
These data suggest that beta1 and beta4 have antagonistic roles, the former favoring inactivation, and the latter favoring activation.
Title: Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.
down-regulation of Scn4b may lead to abnormalities of sodium channel and neurite degeneration in the striatum of Huntington's disease transgenic mice
Title: Sodium channel beta4 subunit: down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AV node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell action potential involved in contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell action potential involved in contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization during cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane depolarization during cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	IC Inferred by Curator more info	PubMed
part_of voltage-gated sodium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated sodium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: sodium channel regulatory subunit beta-4

Names: sodium channel accessory subunit; sodium channel subunit beta-4; sodium channel, type IV, beta polypeptide; voltage gated sodium channel beta 4 subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.