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CG6951 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40222, updated on 4-Jan-2025

Summary

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Official Symbol
CG6951provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036959
Locus tag
Dmel_CG6951
See related
AllianceGenome:FB:FBgn0036959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.579; Dmel\CG6951
Summary
Predicted to enable dCMP deaminase activity. Predicted to be involved in cytidine deamination; dTMP biosynthetic process; and dUMP biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6951 in Genome Data Viewer
Location:
77A3-77A4; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20241267..20245312)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20234367..20238412)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 3-3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Clathrin light chain Neighboring gene retinal degeneration C Neighboring gene antisense RNA:CR43876 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster. Bogaerts-Márquez M, et al. Mol Ecol, 2021 Feb. PMID 33350518, Free PMC Article
  2. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
  3. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dCMP deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dUMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6951-PA
CG6951-PB
NP_649197.1
NP_730502.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20241267..20245312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168838.3 → NP_730502.1  uncharacterized protein Dmel_CG6951, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730502.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XF4, Q9VWA2
    UniProtKB/TrEMBL
    L7VG69
    Related
    FBpp0074597
    Conserved Domains (1) summary
    cd01286
    Location:29 → 164
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  2. NM_140940.3 → NP_649197.1  uncharacterized protein Dmel_CG6951, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649197.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XF4, Q9VWA2
    UniProtKB/TrEMBL
    L7VG69
    Related
    FBpp0074598
    Conserved Domains (1) summary
    cd01286
    Location:29 → 164
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWA2.1 Q9VWA2

Gene LinkOut

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