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Hpf1 Histone PARylation factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40718, updated on 9-Dec-2024

Summary

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Official Symbol
Hpf1provided by FlyBase
Official Full Name
Histone PARylation factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0037377
Locus tag
Dmel_CG1218
See related
AllianceGenome:FB:FBgn0037377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1218; dHpf1; Dmel\CG1218
Summary
Enables poly-ADP-D-ribose binding activity and zinc ion binding activity. Involved in DNA damage response. Is active in site of DNA damage. Is expressed in several structures, including antennal primordium; anterior endoderm; ganglia; head epidermis primordium; and mesoderm. Orthologous to human HPF1 (histone PARylation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Hpf1 in Genome Data Viewer
Location:
83C4-83C4; 3-47.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5791879..5793383)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1617601..1619105)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene katanin p60-like 1 Neighboring gene Histone acetyltransferase 1 Neighboring gene Regulatory particle non-ATPase 5 Neighboring gene Proteasome assembly chaperone 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure of a zinc-finger domain that binds to poly-ADP-ribose. Isogai S, et al. Genes Cells, 2010 Feb. PMID 20088964
  2. A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance. Valakh V, et al. Dev Biol, 2012 Jun 15. PMID 22542760, Free PMC Article
  3. Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Fontana P, et al. Nat Commun, 2023 Jun 2. PMID 37268618, Free PMC Article
  4. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. Gibbs-Seymour I, et al. Mol Cell, 2016 May 5. PMID 27067600, Free PMC Article
  5. Integrating computational biology and forward genetics in Drosophila. Aerts S, et al. PLoS Genet, 2009 Jan. PMID 19165344, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly-ADP-D-ribose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone PARylation factor 1
Names
CG1218-PA
Hpf1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5791879..5793383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141332.4 → NP_649589.1  histone PARylation factor 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649589.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T050, Q9VNI3
    Related
    FBpp0078279
    Conserved Domains (2) summary
    pfam10228
    Location:178 → 428
    DUF2228; uncharacterized conserved protein (DUF2228)
    pfam10283
    Location:4 → 25
    zf-CCHH; Zinc-finger (CX5CX6HX5H) motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNI3.2 Q9VNI3

Gene LinkOut

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