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MEF2A myocyte enhancer factor 2A [ Bos taurus (domestic cattle) ]

Gene ID: 407231, updated on 1-Jan-2025

Summary

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Official Symbol
MEF2Aprovided by VGNC
Official Full Name
myocyte enhancer factor 2Aprovided by VGNC
Primary source
VGNC:VGNC:31372
See related
BGD:BT12322; Ensembl:ENSBTAG00000010649
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See MEF2A in Genome Data Viewer
Location:
chromosome: 21
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (6860314..7040879, complement)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 17 Neighboring gene uncharacterized LOC132343325 Neighboring gene LysM domain containing 4 Neighboring gene uncharacterized LOC132343326 Neighboring gene leucine rich repeat containing 28

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells. Sun J, et al. Genes (Basel), 2023 Jul 22. PMID 37510401, Free PMC Article
  2. Myocyte enhancer factor 2A promotes proliferation and its inhibition attenuates myogenic differentiation via myozenin 2 in bovine skeletal muscle myoblast. Wang YN, et al. PLoS One, 2018. PMID 29698438, Free PMC Article
  3. Promoter variant-dependent mRNA expression of the MEF2A in longissimus dorsi muscle in cattle. Juszczuk-Kubiak E, et al. DNA Cell Biol, 2012 Jun. PMID 22320864, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells.
    Title: Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells.
  2. MEF2A is a positive regulator in skeletal muscle myoblast proliferation
    Title: Myocyte enhancer factor 2A promotes proliferation and its inhibition attenuates myogenic differentiation via myozenin 2 in bovine skeletal muscle myoblast.
  3. polymorphisms in the bovine MEF2A gene and their effect on the MEF2A mRNA expression level in the longissimus dorsi muscle
    Title: Promoter variant-dependent mRNA expression of the MEF2A in longissimus dorsi muscle in cattle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myocyte-specific enhancer factor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083638.2 → NP_001077107.1  myocyte-specific enhancer factor 2A

    See identical proteins and their annotated locations for NP_001077107.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133487
    UniProtKB/Swiss-Prot
    A2VDZ3
    Related
    ENSBTAP00000014074.4, ENSBTAT00000014074.5
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    6860314..7040879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005221713.5 → XP_005221770.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_005221770.1

    UniProtKB/TrEMBL
    D2KFG0
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  2. XM_005221712.5 → XP_005221769.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_005221769.1

    UniProtKB/TrEMBL
    D2KFG0
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  3. XM_005221716.5 → XP_005221773.1  myocyte-specific enhancer factor 2A isoform X3

    See identical proteins and their annotated locations for XP_005221773.1

    UniProtKB/TrEMBL
    A0A3Q1MDU1
    Related
    ENSBTAP00000068625.1, ENSBTAT00000076961.2
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  4. XM_005221715.5 → XP_005221772.1  myocyte-specific enhancer factor 2A isoform X2

    See identical proteins and their annotated locations for XP_005221772.1

    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  5. XM_059878953.1 → XP_059734936.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    D2KFG0

  6. XM_059878955.1 → XP_059734938.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    D2KFG0

  7. XM_059878952.1 → XP_059734935.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    D2KFG0

  8. XM_059878954.1 → XP_059734937.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    D2KFG0

  9. XM_059878956.1 → XP_059734939.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    D2KFG0

  10. XM_059878958.1 → XP_059734941.1  myocyte-specific enhancer factor 2A isoform X6

  11. XM_010816885.4 → XP_010815187.1  myocyte-specific enhancer factor 2A isoform X5

    See identical proteins and their annotated locations for XP_010815187.1

    Conserved Domains (1) summary
    pfam12347
    Location:14 → 66
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  12. XM_059878957.1 → XP_059734940.1  myocyte-specific enhancer factor 2A isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2VDZ3.1 GenPept UniProtKB/Swiss-Prot:A2VDZ3

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