gpp grappa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gppprovided by FlyBase
Official Full Name: grappaprovided by FlyBase
Primary source: FLYBASE:FBgn0264495
Locus tag: Dmel_CG42803
See related: AllianceGenome:FB:FBgn0264495
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0732/14; anon-WO0118547.319; BcDNA:SD05230; CG10272; CG33324; CG42803; dDot1; dDOT1L; Dmel\CG42803; DOT1L; EN3-1; Gpp; grp; l(3)03342; l(3)S073214b; l(3)sA3484
Old locus tag: Dmel_CG10272; Dmel_CG33324
Summary: Enables histone H3K79 dimethyltransferase activity and histone H3K79 monomethyltransferase activity. Involved in subtelomeric heterochromatin formation and transcription initiation-coupled chromatin remodeling. Located in nucleus. Used to study syndromic intellectual disability. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (6406855..6449274)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2232577..2274996)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables histone H3K79 dimethyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K79 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K79 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K79 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K79 monomethyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in pericentric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in subtelomeric heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone methyltransferase complex	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Names: CG42803-PB; CG42803-PC; CG42803-PD; CG42803-PE; CG42803-PF; enhancer of NA9 3-1; gpp-PB; gpp-PC; gpp-PD; gpp-PE; gpp-PF; lethal (3) S073214b