Elp1 Elongator complex protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Elp1provided by FlyBase
Official Full Name: Elongator complex protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0037926
Locus tag: Dmel_CG10535
See related: AllianceGenome:FB:FBgn0037926
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10535; D-elp1; Dmel\CG10535; elp1; ELP1
Summary: Predicted to enable tRNA binding activity. Involved in dosage compensation by hyperactivation of X chromosome; establishment of mitotic spindle asymmetry; and long-term memory. Part of elongator holoenzyme complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; hindgut proper primordium; and larval muscle system. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; kyphosis; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11650971..11655691)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7476693..7481413)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dosage compensation by hyperactivation of X chromosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle asymmetry	IDA Inferred from Direct Assay more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of elongator holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of elongator holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of elongator holoenzyme complex	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain