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CRB2 crumbs 2, cell polarity complex component [ Gallus gallus (chicken) ]

Gene ID: 417104, updated on 17-Aug-2024

Summary

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Symbol
CRB2provided by CGNC
Full Name
crumbs 2, cell polarity complex componentprovided by CGNC
Primary source
CGNC:50440
See related
Ensembl:ENSGALG00010028326
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See CRB2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (9560600..9626663)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (8971124..9040641)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene uncharacterized LOC121107051 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene U4 spliceosomal RNA Neighboring gene DENN domain containing 1A Neighboring gene uncharacterized LOC112529972

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein crumbs homolog 2
Names
crumbs family member 2
crumbs homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9560600..9626663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015279573.4 → XP_015135059.1  protein crumbs homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V1ADD1
    Conserved Domains (5) summary
    smart00179
    Location:416 → 444
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:129 → 165
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:503 → 664
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:691 → 720
    EGF; EGF-like domain
    pfam02210
    Location:758 → 875
    Laminin_G_2; Laminin G domain

  2. XM_004946009.5 → XP_004946066.1  protein crumbs homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1ADD1, E1BYW1
    Related
    ENSGALP00010042178.1, ENSGALT00010068588.1
    Conserved Domains (5) summary
    smart00179
    Location:474 → 502
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:187 → 223
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:561 → 722
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:749 → 778
    EGF; EGF-like domain
    pfam02210
    Location:816 → 933
    Laminin_G_2; Laminin G domain

  3. XM_004946010.5 → XP_004946067.1  protein crumbs homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V1ADD1, A0A8V1AI95
    Related
    ENSGALP00010042180.1, ENSGALT00010068593.1
    Conserved Domains (5) summary
    smart00179
    Location:474 → 502
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:187 → 223
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:561 → 722
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:749 → 778
    EGF; EGF-like domain
    pfam02210
    Location:816 → 933
    Laminin_G_2; Laminin G domain

  4. XM_040649129.2 → XP_040505063.1  protein crumbs homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A8V1ADD1
    Conserved Domains (3) summary
    smart00179
    Location:474 → 502
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:187 → 223
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:561 → 722
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RNA

  1. XR_005840395.2 RNA Sequence

  2. XR_003070956.3 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    8971124..9040641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040685515.2 → XP_040541449.1  protein crumbs homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V1ADD1
    Conserved Domains (5) summary
    smart00179
    Location:416 → 444
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:129 → 165
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:503 → 664
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:691 → 720
    EGF; EGF-like domain
    pfam02210
    Location:758 → 875
    Laminin_G_2; Laminin G domain

  2. XM_040685513.2 → XP_040541447.1  protein crumbs homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1ADD1, E1BYW1
    Conserved Domains (5) summary
    smart00179
    Location:474 → 502
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:187 → 223
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:561 → 722
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:749 → 778
    EGF; EGF-like domain
    pfam02210
    Location:816 → 933
    Laminin_G_2; Laminin G domain

  3. XM_040685514.2 → XP_040541448.1  protein crumbs homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V1ADD1, A0A8V1AI95
    Conserved Domains (5) summary
    smart00179
    Location:474 → 502
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:187 → 223
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:561 → 722
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:749 → 778
    EGF; EGF-like domain
    pfam02210
    Location:816 → 933
    Laminin_G_2; Laminin G domain

  4. XM_040685516.2 → XP_040541450.1  protein crumbs homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A8V1ADD1
    Conserved Domains (3) summary
    smart00179
    Location:474 → 502
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:187 → 223
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:561 → 722
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RNA

  1. XR_005854628.2 RNA Sequence

  2. XR_005854627.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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