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FKBP5 FK506 binding protein 5 [ Gallus gallus (chicken) ]

Gene ID: 421186, updated on 3-Dec-2024

Summary

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Symbol
FKBP5provided by CGNC
Full Name
FK506 binding protein 5provided by CGNC
Primary source
CGNC:627
See related
Ensembl:ENSGALG00010026893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
FKBP51; PPIase
Orthologs
human mouse all
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Genomic context

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See FKBP5 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 26 NC_052557.1 (113126..131730, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 26 NC_052598.1 (82136..101232, complement)

Chromosome 26 - NC_052557.1Genomic Context describing neighboring genes Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene TEA domain transcription factor 3 Neighboring gene tubby like protein 1 Neighboring gene colipase Neighboring gene lipoma HMGIC fusion partner-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glucocorticoids modulate NF-kappaB-dependent gene expression by up-regulating FKBP51 expression in Newcastle disease virus-infected chickens. Park J, et al. Mol Cell Endocrinol, 2007 Nov 15. PMID 17870233
  2. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
  3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that systemic elevation of FKBP51 in NDV-infected chickens activates NF-kappaB, which cooperates with other factors to regulate the expression of NF-kappaB-dependent genes.
    Title: Glucocorticoids modulate NF-kappaB-dependent gene expression by up-regulating FKBP51 expression in Newcastle disease virus-infected chickens.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP5
Names
51 kDa FK506-binding protein
rotamase
NP_001005431.1
XP_015154202.1
XP_024999481.1
XP_040508684.1
XP_040508685.1
XP_046760099.1
XP_046788981.1
XP_046788982.1
XP_046788983.1
XP_046788984.1
XP_046788985.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005431.1 → NP_001005431.1  peptidyl-prolyl cis-trans isomerase FKBP5

    See identical proteins and their annotated locations for NP_001005431.1

    Status: PROVISIONAL

    Source sequence(s)
    AY723747
    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7
    Conserved Domains (3) summary
    TIGR00990
    Location:230 → 397
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:319 → 345
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:44 → 135
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    113126..131730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040652751.2 → XP_040508685.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7
    Conserved Domains (3) summary
    TIGR00990
    Location:230 → 397
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:319 → 345
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:44 → 135
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. XM_046904143.1 → XP_046760099.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X2

    UniProtKB/TrEMBL
    A0A8V1A943

  3. XM_015298716.4 → XP_015154202.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7
    Related
    ENSGALP00010039738.1, ENSGALT00010065274.1
    Conserved Domains (3) summary
    TIGR00990
    Location:230 → 397
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:319 → 345
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:44 → 135
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  4. XM_040652750.2 → XP_040508684.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7
    Related
    ENSGALP00010039737.1, ENSGALT00010065269.1
    Conserved Domains (3) summary
    TIGR00990
    Location:230 → 397
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:319 → 345
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:44 → 135
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  5. XM_025143713.3 → XP_024999481.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7
    Conserved Domains (3) summary
    TIGR00990
    Location:230 → 397
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:319 → 345
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:44 → 135
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    82136..101232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046933027.1 → XP_046788983.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7

  2. XM_046933029.1 → XP_046788985.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7

  3. XM_046933025.1 → XP_046788981.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7

  4. XM_046933026.1 → XP_046788982.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7

  5. XM_046933028.1 → XP_046788984.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P953, A0A8V1A943, E1C4X2, Q646T7
Nucleotide Protein Strain
Heading Accession and Version

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